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Página 1 a partir de 1890 resultados
A common pathway in periodic fever syndromes.
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Familial Mediterranean fever (FMF) is an autosomal recessive disease due to mutations in pyrin, which normally inhibits pro-interleukin-1beta (IL-1beta) cytokine processing to the active form. A novel role for pyrin has been proposed by Shoham et al., who studied patients with an autosomal dominant
[Study of urinary proline and hydroxyproline in the common rickets of childhood].
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A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans.
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BACKGROUND
The alcohol dehydrogenase (ADH) genes have been repeatedly associated with protection against alcoholism. Until now, only four protein coding variants have been identified (ADH1C Arg271Gln, Ile349Val, ADH1B Arg47His, and Arg369Cys), and only two of these (ADH1CIle349Val and ADH1B
Colostrinin decreases hypersensitivity and allergic responses to common allergens.
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BACKGROUND
Colostrinin (CLN), isolated from mothers' pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta-amyloid-induced apoptosis
Grb10 exceeding the boundaries of a common signaling adapter.
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Growth factor receptor binding protein 10 (Grb10) has been identified as a cellular partner of a number of receptor tyrosine kinases and other signaling mediators, compatible with multiple roles in mitogenic, metabolic, and embryogenic signaling that are also supported by the tissue distribution of
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.
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Transforming growth factor-beta (TGF-beta)/activin-induced Smad2/Smad4 complexes are recruited to different promoter elements by transcription factors, such as Fast-1 or the Mix family proteins Mixer and Milk, through a direct interaction between Smad2 and a common Smad interaction motif (SIM) in
Assessment of common plant parameters as biomarkers of air pollution.
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Air pollution is a very serious current environmental issue of human society. Large parts of countries, especially the densely populated cities, having high vehicular movement, industries, and factories, are worst affected. Biomarkers are changes in plant parameters that help in easy assessment of
Human PZP and common marmoset A2ML1 as pregnancy related proteins.
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While pregnancy-related proteins (PRP) are known to contribute to immunotolerance during pregnancy, their significance to development of invasive placenta is unclear. We compared PRP expression in humans and the common marmoset (Callithrix jacchus), a new-world monkey. Invasive placenta was observed
Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles.
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Hypoxia-inducible transcription factor (HIF), an αβ dimer, is the key inducer of hypoxia-responsive genes that operate both during normal development and pathological processes in association with decreased oxygen availability. The products of HIF target genes function in, e.g., hematopoiesis,
Computational predictions of common transcription factor binding sites on the genes of proline metabolism in plants.
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Proline, an imino acid, has been well documented to be associated with the stress response induced by abiotic factors such as drought, cold and salinity in plants and biotic factors such as bacterial and fungal attacks. However, the regulatory mechanisms controlling proline metabolism, intercellular
Characterization and gene expression of nodulin Npv30 from common bean.
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We previously reported that transcripts for a 30-kD nodulin (Npv30) are very abundant in the nodule. In this paper we describe the isolation and characterization of Npv30 cDNA and genomic clones. Npv30 has the following characteristic features: (a) a putative signal sequence at the deduced
Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety.
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The following NEKY have been studied: 1-kynurenine (KYN), 3-hydroxyKYN (3HKYN), kynurenic (KYNA), anthranilic (ANT), 3-hydroxyANT (3HANT), quinolinic (QUIN), picolinic (PICA), xanthurenic (XAN), nicotinic (NIC) acids, 3-indole-pyruvate (IPA), nicotinamide (NAM). NEKY antagonize the central effects
Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline.
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The initial step in the degradation pathways of proline and hydroxyproline is catalyzed by proline oxidase and hydroxyproline oxidase, yielding delta 1-pyrroline-5-carboxylate and delta 1-pyrroline-3-hydroxy-5-carboxylate, respectively. The second step is the oxidation of delta
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
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With bacterial resistance becoming a serious threat to global public health, antimicrobial peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are derived from a diverse range of species, from prokaryotes to humans, with a mechanism of action that often involves
PyTMs: a useful PyMOL plugin for modeling common post-translational modifications.
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BACKGROUND
Post-translational modifications (PTMs) constitute a major aspect of protein biology, particularly signaling events. Conversely, several different pathophysiological PTMs are hallmarks of oxidative imbalance or inflammatory states and are strongly associated with pathogenesis of
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