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Simultaneous degeneration of myenteric plexuses and pelvic parasympathetic colonic nerve in slow transit constipation: A case report.

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BACKGROUND Slow transit constipation (STC) is a common disease of which the etiology is still not clear. Multiple hypotheses have been proposed to explain STC, including autonomic neuropathy, disorders of the enteric nervous system and so forth. Morphological abnormalities of the enteric nerves of

Macrogol 3350/electrolyte improves constipation in Parkinson's disease and multiple system atrophy.

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We describe an open study of macrogol 3350 in 10 cases of constipated patients with Parkinson's disease or multiple system atrophy. The agent produced a marked improvement in symptoms in all cases.

[Clinical pathological conferences of the Hospital of Nutritional Diseases; melena, constipation and general deterioration].

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Dietary herb extract dai-kenchu-to ameliorates constipation in parkinsonian patients (Parkinson's disease and multiple system atrophy).

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Calcium polycarbophil improves constipation in primary autonomic failure and multiple system atrophy subjects.

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[An autopsy case of multiple system atrophy presenting with rapid progression of autonomic disturbance].

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We report an autopsy case of multiple system atrophy (MSA) presenting with rapid progression of autonomic disturbance. He was admitted to our hospital because of gait disturbance and dysarthria. The patient was a Japanese man, who first noticed gait disturbance and dysarthria at age 58, followed by

Megacolon in third-phase malrotation with delayed migration and degeneration of intramural ganglionic cells and nerves.

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A woman of 36 was admitted to hospital because of griping abdominal pain which occurred especially during the night when turning in bed. She had a history of constipation and bloating since birth. Irrigoscopy revealed megacolon extending from the middle of the transverse colon to the rectum. A

[A case of adult-onset tethered cord syndrome accompanied with slowly progressive muscular atrophy in the lower limbs].

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A 70-year-old man developed slowly progressive muscular atrophy in the lower limbs from age 28, followed by urinary disturbance from age 40. Neurological examination revealed bilateral severe muscular atrophy in the lower limbs with hypesthesia and hypalgesia, mild muscle wasting of both hands,

Adrenal insufficiency, myopathic hypotonia, severe psychomotor retardation, failure to thrive, constipation and bladder ectasia in 2 brothers: adrenomyodystrophy.

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Two brothers are described who manifested primary adrenal insufficiency, dystrophic myopathy, severe psychomotor retardation, failure to thrive, fatty degeneration of the liver, megalocornea, chronic constipation, and terminal bladder ectasia until their death at 3 8/12 and 1 7/12 years,

Is constipation a trivial matter?

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Constipation is a common symptom of patients presenting to the emergency department. If poorly managed, it can have significant consequences. A 50-year-old man was admitted to the emergency department following cardiac arrest. His medical history included a diagnosis of cerebral palsy and multiple

Cisapride treatment of constipation in Parkinson's disease.

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Constipation, a frequent symptom in Parkinson's disease (PD), is probably caused by degeneration of the autonomic nervous system, particularly the myenteric plexus. Cisapride is a drug that causes increased release of acetylcholine in the myenteric plexus. In a pilot study, cisapride therapy was

Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists.

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There is an unmet need for effective pharmacological therapies for constipation, a symptom that significantly deteriorates patients' quality of life and impacts health care. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and has been shown to exert prokinetic effects on

[Studies of the results of the surgical treatment of severe forms of constipation in 5 patients].

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A small percent of the population in our country suffer chronic constipation, manifested in various degrees. To surgical treatment are subjected patients with severe decompensated forms of constipation, resulting in a general state deterioration, when the systematic conservative treatment failed to

[Experimental study of Bisacodyl in the treatment of slow transit constipation model rats].

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OBJECTIVE To explore the efficacy and the mechanism of Bisacodyl in treating slow transit constipation model rats. METHODS A total of 30 healthy rats were enrolled. Twenty rats received intragastric diphenoxylate to develop slow transit constipation (STC) model, and 10 untreated rats were set as

[Effect of electroacupuncture at "Tianshu"(ST 25) on colonic smooth muscle structure and interstitial cells of cajal in slow transit constipation rats].

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OBJECTIVE To observe the effect of electroacupuncture (EA) of "Tianshu" (ST 25) on colonic smooth muscle structure and interstitial cells of Cajal (ICC) in slow transit constipation (STC) rats, so as to investigate its mechanism underlying improving STC. METHODS Wistar rats (n = 56) were randomly

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