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13 resultados
The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea.
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The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity
Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis.
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In addition to seven known alkaloids (2, 6-11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3-5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine
In vitro screening for antiplasmodial activity of isoquinoline alkaloids from Brazilian plant species.
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In the search for new antimalarial agents, nine Brazilian plant species were selected, from the Annonaceae (6), Menispermaceae (2) and Siparunaceae (1) families naturally occurring at the cerrado and Atlantic rainforest regions, in order to investigate their in vitro antiplasmodial activity. The
N-nitrosoanonaine and N-nitrosoxylopine, aporphine alkaloids from Duguetia furfuracea.
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Two new aporphine alkaloids, N-nitrosoanonaine (1) and N-nitrosoxylopine (2), were isolated from the aerial parts of Duguetia furfuracea, a weed found in several Brazilian regions. Their structures were elucidated by NMR analysis, CHN analysis, CD, IR, and MS data. The single-crystal X-ray
Isolation of a minor nitro-alkaloid from the aerial parts of Duguetia furfuracea--Annonaceae.
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The refractionation of an alkaloidal extract of the leaves and twigs of Duguetia furfuracea has provided a minor aporphinoid alkaloid, named (+)-8-nitrous-isocorydine or (+)-1,2,3-trymethoxy-11-hydroxy-8-nitrous- aporphine. The structure of the new compound was elucidated by spectroscopic methods,
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
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Bioassay-guided isolation of Duguetia hadrantha yielded two new 4,5-dioxo-1-azaaporphinoids, hadranthine A (1) and hadranthine B (2), together with the known alkaloids imbiline-1 (3), sampangine (4), and 3-methoxysampangine (5), whose structures were determined primarily from 2D-NMR 1H-13C HMBC, and
Studies in aporphine alkaloids. I. Alkaloids of a brazilian Duguetia.
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Alkaloids from the genus Duguetia.
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Antioxidant, anti-rheumatic and anti-inflammatory investigation of extract and dicentrinone from Duguetia furfuracea (A. St.-Hil.) Benth. & Hook. f.
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BACKGROUND
The preparations of teas and syrups using Duguetia furfuracea have been used in folk medicine to treat rheumatism and back pain. Several rheumatic diseases are anti-inflammatory and are treated with several anti-inflammatories.
OBJECTIVE
The objective of this work were to evaluate the
Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata.
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Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline
Antinociceptive activity of discretamine isolated from Duguetia moricandiana.
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The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice,
Endothelium-derived nitric oxide is involved in the hypotensive and vasorelaxant effects induced by discretamine in rats.
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The aim of this study was to investigate the pharmacological effects of discretamine, an isoquinoline alkaloid isolated from Duguetia magnolioidea Maas, on the cardiovascular system, using a combined in vivo and in vitro approach. Blood pressure and heart rate measurements, as well as changes in
Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster.
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Duguetia furfuracea is frequently used as a medicinal plant in Brazil. However, studies have evidenced its cytotoxic, bactericide, and antitumor activities. In the present study we aimed to evaluate the potential toxicity of hydroalcoholic leaves extracts of D. furfuracea (HEDF) in a Drosophila
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