The invention relates to a method for protecting transplants, as well as organs and individual blood vessels, against inflammatory reactions that are caused by the operative procedure linked to the explantation and storage until transplantation. This can be achieved by treating the transplant via intra arterial application of flavonol compounds, in particular with quercetin glucuronide and/or kaempferol glucuronide.

Esperester; Anke

Nees; Stephan

Boehringer Ingelheim International GmbH

Method for the anti-inflammatory protection of transplants using quercetin glucuronide

Compositions and pharmaceutical compositions are described which comprise: a component A comprising one or more flavonol glycosides, a component B comprising one or more tetrahydrofolic acid compounds, a component C comprising one or more calcium supplements, and a component D comprising one or more magnesium supplements. Methods of using such compositions and pharmaceutical compositions to treat and/or prevent osteoporosis and/or an inflammatory joint disease are also described.

Merck Patent Gesellschaft mit beschrankter Haftung

Compositions for the treatment of inflammatory joint diseases and osteoporosis

The preparation of extracts of seed coats of lentil (Lens esculenta) as a representative member of the Leguminosae, extracted with a range of volatile solvents, such as methanol, acetone, singly or a mixture with water, and food solvents, such as ethyl acetate and ethanol, to yield such extracts that are water-soluble, which contain a rich mixture of condensed tannins (procyanidins and prodciphinidin as glycosides), together with a flavanone (luteolin) and flavonols (quercetin, kaempferol) and phenolic acids (ferulic acid, protocatechuic acid, caffeic acid) and which possess the ability to quench organic free radicals, to scavenge superoxide, to inhibit the oxidation of water soluble nutrients such as vitamin C, as well as the oxidation of fat-soluble nutrients such as essential fatty acids, and to limit damage due to oxidants linked to inflammatory conditions, and to inhibit certain cells responsible for inflammation, is disclosed.

flavonol/inflamação

Method for the anti-inflammatory protection of transplants using quercetin glucuronide

Compositions for the treatment of inflammatory joint diseases and osteoporosis

Antioxidant derived from lentil and its preparation and uses

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