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gamma linolenate/cancro da mama
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Differential responses of human tumor-cells to polyunsaturated Fatty-acids - stimulation of proliferation of a colon-tumor cell-line by docosahexaenoic Acid.
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The potential differential effects of polyunsaturated fatty acids (5-100 mu g/ml) on four human tumour cell lines of different origin and a human fibroblast cell line were investigated. Following 6 days exposure to the fatty acids, gamma linolenic acid, eicosapentaenoic acid, and docosahexaenoic
Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro.
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Polyunsaturated fatty acids (PUFAs) have been shown to inhibit both normal and tumor cell growth in vitro. As PUFAs are known to induce a respiratory burst and free radical generation in polymorphonuclear leukocytes and since free radicals are toxic to cells, we investigated the effect of PUFAs on a
Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation.
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The contribution of lipid peroxidation to the killing of human breast cancer cells by gamma-linolenate (GLA) was examined. Other fatty acids of different cytotoxic potential containing 2, 4, 5, and 6 double bonds were also tested for comparison. It was found that the cytotoxic potential varied with
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