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Página 1 a partir de 43 resultados
Proline trapping in granulomas, the site of collagen biosynthesis in murine schistosomiasis.
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Proline, a critical substrate for collagen synthesis, is increased in liver undergoing fibrosis. In mice with schistosomiasis, the incorporation of proline into collagen occurs within liver granulomas. To study the interaction of liver cells and granulomas in the development of fibrosis, we assayed
Collagen proline hydroxylase in wound healing, granuloma formation, scurvy, and growth.
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Compared to homologous tissues from adult animals, rapidly growing embryonic and fetal tissues contain large amounts of collagen proline hydroxylase. Lung and skin from scorbutic guinea pigs contain one-third as much enzyme as normal tissues do. A rapid increase in proline hydroxylase occurs on the
Identification in the rat skin and subcutaneous granuloma of an enzyme liberating N-terminal glycyl-proline from peptides.
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COLLAGEN SYNTHESIS AND C14-LABELED PROLINE UPTAKE AND CONVERSION TO HYDROXYPROLINE IN STEROID-TREATED GRANULOMAS.
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Tritiated proline in macrophages. In vivo and in vitro uptake by foreign-body granulomas.
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The relation of ascorbic acid to the conversion of proline to hydroxyproline in the synthesis of collagen in the carrageenan granuloma.
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Effect of 2-aminoethyl-L-cysteine on collagen accumulation in isolated hepatic granulomas.
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Hydroxylysine residues are important structural components of collagen as sites of glycosylation and cross-linking. Because hydroxylysine is formed from lysine by post-translational enzymatic hydroxylation, we examined the effects of incorporation of a lysine analogue that could interfere with
Schistosoma mansoni: higher free proline levels in the livers of infected mice.
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The concentration of L-hydroxyproline in the liver of ICR female mice increased rapidly during the 8th to 11th weeks of Schistosoma mansoni infection. Free L-proline concentration began to increase about the 7th week and reached its maximum at the 8th to 9th weeks of the infection, when the
Proline-oxidase and hydroxypyroline-2-epimerase activities in experimental fibrosing granulomatous processes of the lung.
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Three experimental fibrosing granulomatous processes of the lung (pulmonary granulomas induced by complete Freund adjuvant, viral pneumonitis induced by the A2 influenza virus, and tuberculosis induced in animals exposed to tobacco smoke) were produced in rabbits and the results confronted in view
Comparison of mycobacterial granulomas in guinea-pig lymph nodes.
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A study was made of mycobacterial-induced granulomas in guinea-pig lymph nodes. Live BCG (Pasteur) induced a granuloma containing epithelioid cells while Cobalt irradiated Mycobacterium leprae induced a granuloma comprised of phagocytic macrophages. The granulomas were quantitated by measurement of
A biochemical study of the carrageenan-induced granuloma in the rat lung.
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Intralobular injection of carrageenan in the rat lung induced a chronic granulomatous response, characterized by a prolonged accumulation of macrophages within the affected lobe. This was accompanied by moderate but significant increases in lysosomal beta-acetyl glucosaminidase, cathepsin B1, and
Treatment of experimental silicosis with antifibrotic agents.
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We tested the efficacy of 2 antifibrotic agents, the proline analogue cis-4-hydroxy-L-proline (cHyp) and the lathyrogen beta-aminopropionitrile (BAPN), on experimental silicosis in hamsters. Silica (75 mg) was instilled intratracheally, and 3 months later lung hydroxyproline content, the volume
Healing of anastomoses after obstruction of small intestine.
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Anastomotic healing after obstruction of the small intestine was investigated by measurements of development of strength, content of collagen and synthesis of collagen in standardized specimens taken at biopsy of the intestinal wall on both sides of the anastomosis. One hundred and sixteen male
Experimental silicosis. I. Acute effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.
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Rats were intratracheally instilled with 50 mg of silica as quartz (0.5-mu particles) at day 0. One and 2 weeks later, lungs were evaluated histologically and by a variety of biochemical measurements. Protein, proline, and hydroxyproline content (as an index of total lung collagen) were quantitated,
Different responses to some stimulators of prolyl hydroxylase activities in various rat organs.
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Prolyl hydroxylase (proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) of soluble fraction (105 000 X g supernatant) of rat granulation tissues was markedly enhanced by addition of nucleoside triphosphates to the assay medium. But the stimulatory activities of nucleoside triphosphates were very
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