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Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them
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The invention relates to diacyl-substituted guanidines of the formula I ##STR3##
in which: X(1) and X(2) are ##STR4## T1 is zero, 1, 2, 3 or 4, R(A) and R(B) are, independently, hydrogen, F, Cl, Br, I, CN, OR(106), (C.sub.1 -C.sub.8)-alkyl, (C.sub.3 -C.sub.8)-cycloalkyl, O.sub.zk (CH.sub.2).sub.zl
(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit nitochondrial F.sub.1 F.sub.0 ATP hydrolase and are useful for treating ischemia-related diseases. The invention further pertains to methods of treating conditions associated with depleted levels of adenosine triphosphate (ATP)
Substituted thiophenylalkenylcarboxylic acid guanidines, processes for their preparation, their use as a medicament or diagnositc, and a medicament containing them
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SUMMARY OF THE INVENTION
The invention relates to substituted thiophenylalkenylcarboxylic acid guanidides of the formula I ##STR2## in which: at least one of the substituents R(1), R(2) and R(3) is --Op--(CH.sub.2).sub.s --C.sub.q F.sub.2q+1 R(40)CO-- or R(31)SO.sub.k --;
p is zero or 1;
s is zero,
Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
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DESCRIPTION
Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them.
The invention relates to benzoylguanidines of the formula I ##STR3## in which:
R(1), R(3) or R(4) is --NR(6) C.dbd.X NR(7)R(8),
X is oxygen,
3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them
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The invention relates to benzoylguanidines of the formula I
in which:
R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, where
m is zero, 1 or 2,
R(4) and R(5) are C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -alkenyl or --C.sub.n H.sub.2n --R(7),
n is zero, 1, 2, 3 or 4,
R(7) is C.sub.5 -C.sub.7
Substituted benzoylguanidines, their use as a medicament or diagnostic, and medicament containing them
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The invention relates to benzoylguanidines of the formula I ##STR3## in which:
R(1) is hydrogen, F, Cl, Br, I, --NO.sub.2, --C.tbd.N, --X.sub.o --(CH.sub.2).sub.p --(CF.sub.2).sub.q --CF.sub.3, R(5) --SO.sub.m --, R(6)--CO--, R(6)R(7)N--CO-- or R(6)R(7)N--SO.sub.2 --;
X is oxygen, --S-- or NR(14);
m
Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
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The invention relates to benzoylguanidines of the formula I ##STR3## in which R(1) is hydrogen, F, Cl, Br, I, --NO.sub.2, --C.tbd.N, R(16)-C.sub.p H.sub.2p --O.sub.q, R(4)-SO.sub.m or R(5)R(6)N--SO.sub.2 --;
p is zero, 1, 2 or 3;
q is zero or 1;
R(16) is C.sub.r F.sub.2r+1 ;
r is 1, 2 or 3,
m is
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