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Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients.

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OBJECTIVE To identify the two polymorphisms of microsomal triglyceride transfer protein (MTP) gene in the Chinese population and to explore their correlation with both hepatitis B virus (HBV) self-limited infection and persistent infection. METHODS A total of 316 subjects with self-limited HBV

Structure of hepatitis B surface antigen. Characterization of the lipid components and their association with the viral proteins.

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The lipid composition of hepatitis B surface antigen (HBsAg) (subtype adw) obtained from different carriers has been determined and proven to be truly characteristic of HBsAg and not subject to individual variation. Phosphatidylcholine (approximately 60%), cholesteryl ester (approximately 14%),

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

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Hepatitis B Virus (HBV) is a strictly hepatotropic pathogen which is very efficiently targeted to the liver and into its host cell, the hepatocyte. The sodium taurocholate co-transporting polypeptide (NTCP) has been identified as a key virus entry receptor, but the early steps in the virus life

Phase I, First-in-Human, Single and Multiple Ascending Dose- and Food-Effect Studies to Assess the Safety, Tolerability and Pharmacokinetics of a Novel Anti-hepatitis B Virus Drug, Bentysrepinine (Y101), in Healthy Chinese Subjects.

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Bentysrepinine (Y101), a derivative of repensine (a compound isolated from Dichondra repens Forst), is a novel phenylalanine dipeptide currently under development for the treatment of hepatitis B virus (HBV). The objectives of these studies were to assess the safety, tolerability and

Viral and host causes of fatty liver in chronic hepatitis B.

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OBJECTIVE To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage. METHODS A total of 164 patients (113 males and 51 females, average age 35+/-11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B

Metabolic investigations in patients with hepatitis B and C.

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OBJECTIVE To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C, clinically and metabolically. METHODS Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison

Hepatic steatosis in chronic hepatitis B: a study of metabolic and genetic factors.

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Hepatic steatosis is a common finding in liver biopsy and may co-exist with chronic hepatitis B (CHB) infection. The aims of this study were to determine the prevalence of steatosis in CHB patients among Filipinos; determine the factors related to the presence of steatosis among individuals with and

Controlled attenuation parameter for the detection of hepatic steatosis in patients with chronic hepatitis B.

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BACKGROUND Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing liver steatosis based on vibration-controlled transient elastography. The primary objective of this study was to assess CAP performance and determine the cut-off values for the diagnosis of hepatic steatosis in

Insulin resistance in chronic hepatitis B virus infection.

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OBJECTIVE Chronic hepatitis C virus infection is associated with insulin resistance (IR), and both host and viral factors are important in its development. The association and the predictors of IR in chronic hepatitis B virus (CHBV) infection remain unclear. METHODS A total of 69 CHBV-infected

Simultaneous extraction of hepatitis C virus (HCV), hepatitis B virus, and HIV-1 from plasma and detection of HCV RNA by a reverse transcriptase-polymerase chain reaction assay designed for screening pooled units of donated blood.

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BACKGROUND Testing for viral nucleic acids should reduce the residual risk of transmitting viral infections by transfusion of blood components. The AmpliScreen Hepatitis C (HCV) Test, Version 2.0, was designed for screening pools composed of samples from individual units of blood or

Hepatic steatosis in chronic hepatitis B: contributing factors and effect on fibrosis.

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OBJECTIVE To determinate factors that contribute to the steatosis's formation in chronic hepatitis B, to evaluate its influence on the development of hepatic fibrosis and to research an eventual relation to virologic factors in a Tunisian cohort of patients. METHODS All patients with chronic

Abnormal liver function test results are related to metabolic syndrome and BMI in Taiwanese adults without chronic hepatitis B or C.

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BACKGROUND Metabolic syndrome (MS) is considered a cause of abnormal deposition of fat into hepatocytes, which might be associated with hepatic steatosis or abnormal liver function. OBJECTIVE The aim of this study was to explore the factors associated with MS and the relationship between MS and

Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers.

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OBJECTIVE This study aimed to investigate the association between serum adiponectin and chronic hepatitis B virus (HBV) infection. METHODS We conducted a campus-based cross-sectional study in Northern Taiwan, an HBV-endemic country. A total of 506 participants, including 147 chronic HBV-infected

Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis.

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Diabetes mellitus has been reported to have an increased prevalence and to be associated with more severe fibrosis in patients with chronic hepatitis C. We evaluated the prevalence of diabetes mellitus in patients with chronic hepatitis B or C as well as the possible association between presence of

Differing characteristics of hepatitis B and C risk factors among elders in a rural area in Taiwan.

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BACKGROUND Both hepatitis B and C are major health concerns in Taiwan. The goal of this study was to determine how risk factors for hepatitis B and C differed in this study population. It was also hoped that the data might help determine how age and place of residence affect hepatitis risk

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