Each capsule contains 400 mg of eicosapentaenoic acid and 200 mg of docosahexaenoic acid. We allocated five capsules per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 2000 mg of eicosapentaenoic acid and 1000 mg of docosahexaenoic acid per day (3 grams of Omega 3 per day) by mouth for 12 weeks. The trademark is Omega Rx Dr.Sears Zone labs Inc.

Each capsule contains 600 mg of soybean oil. We allocated five capusles per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 3000 mg of soybean oil per day (3 gr soya oil per day) by mouth for 12 weeks.

Hypertriglyceridemia

Pediatric Obesity

Each capsule contains 400 mg of eicosapentaenoic acid and 200 mg of docosahexaenoic acid. We allocated five capsules per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 2000 mg of eicosapentaenoic acid and 1000 mg of docosahexaenoic acid per day (3 gr of Omega 3 per day) by mouth for 12 weeks. The trademark is Omega RX Dr.Sears Zone labs Inc.

Omega-3 fatty acid 3 grams per day

Placebo Comparator: Placebo Each capsule contains 600 mg of soybean oil. We allocated five capusles per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 3000 mg of soybean oil per day (3 gr soya oil per day) by mouth for 12 weeks.

Placebo

Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

A Randomized, Double Blind, Placebo-controlled Clinical Trial to Assess the Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

Percent change in triglyceride from baseline to week 12 of study treatment

Fasting Triglycerides from baseline to week 12 of study treatment

Percent Change in cholesterol from baseline to week 12 of study treatment

Fasting Cholesterol from baseline to week 12 of study treatment

Percent Change in HDL-C from baseline to week 12 of study treatment

Fasting HDL-C from baseline to week 12 of study treatment

Percent Change in glucose from baseline to week 12 of study treatment

Fasting glucose from baseline to week 12 of study treatment

Percent Change in Uric Acid from baseline to week 12 of study treatment

Fasting Uric Acid from baseline to week 12 of study treatment

Blanca Estela Del Rio Navarro

Allergy and Pediatric Clinical Immunology

Hospital Infantil de Mexico Federico Gomez

Leija Martinez José de Jesús

Miranda Lora América Liliana

Hall Mondragon Margareth Sharon

Fengyang Huang

Randomized, double-blind, placebo-controlled clinical trial

The Masking intervention had made for investigation subjects and researchers

Control group subjects received the same diet restriction intervention as treatment group. However, their food products did not contain any active component.

Thylakoid group subjects received the same diet restriction intervention as the control group. However, their food products did contain an active component in the form of thylakoid powder.

Metabolic Syndrome

Obesity

Thylakoids

Control

Improvement of Metabolic Health After Thylakoid Supplementation

Metabolic Risk Markers and Body Weight Are Decreased by Green-plant Supplementation in a Pilot Study With Overweight-to-obese Middle-aged Men.

Total cholesterol, LDL, HDL and TAG are measured fasting every fourth week.

P-glucose, p-insulin and HbA1c are measured fasting every fourth week.

CRP and TNF alpha are measured fasting every fourth week.

Ghrelin and leptin are measured fasting every fourth week.

Eva-Lena Stenblom

M.D.

Region Skane

Lund University

Stratified analyses of primary and secondary outcomes based on variables of interest (e.g. sex, age, or BMI) may occur prior to achieving the target for total study enrollment.

Inflammation

USDA, Western Human Nutrition Research Center

USDA Western Human Nutrition Research Center (WHNRC) Cross-Sectional Nutritional Phenotyping Study

Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study

Number and activation level of pro-inflammatory T-helper (Th) cells (Th1, Th2 and Th17), T-regulatory (Treg) cells, and B cells will be measured in fasting blood. Monocytes and neutrophils will be measured in fasting and postprandial blood.

Plasma fatty acid profiles of non-esterified fatty acids, phospholipids, triacylglycerols, red blood cell fatty acids, endocannabinoids, bile acids, eicosanoids and related oxylipins, ceramides, sphingoid bases, acylcarnitines, amino acids and other metabolites measured in response to a challenge meal.

Glucose and insulin measured in response to a challenge meal.

Cholecystokinin, incretins, Peptide YY 3-36, ghrelin measured in response to a challenge meal.

Mononuclear cells or B cells will be measured for MAP kinase activities in fasting and postprandial blood.

Plasma microRNA measured in response to a challenge meal

Transcriptome RNA sequenced in whole blood

DNA sequence from whole blood will be analyzed

Clinical chemistry panel and complete blood count

Height (cm), weight (kg), waist and hip circumference (cm)

Blood pressure (mmHg), pulse rate (beats per minute) and temperature (degrees F).

Body composition (percent body fat) and bone mineral density by Dual energy X-ray Absorptiometry scan.

Resting and postprandial metabolic rates, including respiratory exchange ratios.

Gut microbiota composition and gene content will be assessed in stool using polymerase chain reaction (PCR) and sequencing

The fermentation capacity of microbiota will be measured from a single stool sample

The pathogen resistance capability of microbiota will be measured from a single stool sample

Gut inflammation will be assessed by measuring molecules in stool and/or the response of intestinal epithelial cell cultures to fecal waters from a single stool sample.

Volatile and short chain fatty acids and bile acids will be measured in a single stool sample.

RNA markers will provide a measure of genes expressed by cells of the colon naturally present in a single stool sample

Perceived hunger and fullness will be measured using a visual analog scale. Responses will be a marked on an unsegmented line from 0 or "not at all" to 5 or "extremely."

Breath hydrogen and methane measured in response to a challenge meal.

Random selection of 2 week days and 1 weekend day for 24-hour recall using an automated multi-pass method

Chronic stress questionnaire, food choice questionnaires, and a food preference activity.

Sampling tastes of sweet, salty, and bitter solutions in comparison to water to determine threshold of taste detection.

Spectrophotometric measure of skin pigmentation for assessment of vitamin D status.

Use of the EndoPAT system to measure blood vessel tone.

Pulmonary inflammation measured as exhaled nitric oxide (NO)

Executive function will be assessed using Cambridge Neuropsychological Test Automated Battery (CANTAB) and Iowa Gambling Task

Measured by Wechsler Abbreviated Standard Intelligence test.

Pulse rate (bpm) and recovery after a 3 min YMCA Step Test

The submaximal volume of oxygen consumed during a 4 minute treadmill walking protocol (VO2max) (ml/kg*min)

Use of an accelerometer worn on the hip for 7 days

Monitoring of autonomic balance, cardiac performance, and respiratory measurements and activity using MindWare Mobile Impedance Cardiograph.

An aggregate score derived from measures of urinary cortisol, norepinephrine, epinephrine, blood cholesterol, high sensitivity c-reactive protein, and hemoglobin A1C.

Salivary cortisol measured by enzyme-linked immunosorbent assay (ELISA)

The concentration of aldehydes present in human breath before and after a high-fat meal will be measured by mass spectrometry

Asthma

Allergy

Plant stanol enriched soy-based yoghurt

Soy-based yoghurt without added plant stanols

Maastricht University Medical Centre

Effects of Plant Stanols on Immune Function in Asthma Patients

The Effect of Plant Stanols on the Immune Function of Asthma Patients

Maastricht University Medical Center

Lipid Peroxidation

Sugar drink containing 30 g of cocoa powder and 50 g of a 65% dark chocolate, and the control group received 30 g of placebo drink containing 0 g of cocoa powder. Each drink was prepared by using 300 ml of water and 30 g of sugar, also were consumed twice each day: with breakfast and afternoon meal. during 7-d after the intervention started.

Cocoa powder berverage, dark chocolate bar

Fundación Santa Fe de Bogotá, Universidad Industrial de Santander.

Protective Effects of Cocoa Ingestion Over Healthy Males Plasma Lipids Subjected to Peroxidative Conditions

Oxidative protection of plasma lipids was set up by measuring hexanal, known as one of the main components of oxidizing n-6 polyunsaturated fatty acids (PUFA). The oxidative protection index (OPI), was defined as the difference between the basal and post intervention (cocoa taking in) sample chromatographic areas as stated by the formula: OPI = (Area0 - Area1/ Area0)*100. Hexanal determination was carried out by HS-SPME in situ derivatization method using PFPH fibre saturation as derivatizing agent under the methodology

ORI was expressed as a percentage and held as the difference among basal (0) and post interventions (1) lag time of each subject according to the following formula: ORI = (lag1 - lag0/ lag1)*100. Plasma was 50-fold diluted in a saline phosphate solution (PBS; 0.0027M KCl, 0.137M NaCl, pH 7.4) and then was exposed to copper (II) chloride at final concentration of 95 µM in a 2.5 ml quartz cuvette. Conjugated diene formation from lipid peroxidation was followed at 245 nm wavelength, recorded each 5 min over 4-h period at 37ºC in a Perkin Elmer Lambda Bio 10 spectrophotometer

hypersensitivity/triacylglycerol

Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

Improvement of Metabolic Health After Thylakoid Supplementation

USDA Western Human Nutrition Research Center (WHNRC) Cross-Sectional Nutritional Phenotyping Study

Effects of Plant Stanols on Immune Function in Asthma Patients

Protective Effects of Cocoa Ingestion Over Healthy Males Plasma Lipids Subjected to Peroxidative Conditions

O mais completo banco de dados de ervas medicinais apoiado pela ciência