insulin resistance/edema

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Effects of Fenofibrate Therapy in Diabetic Nephropathy

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In this single-centre, open label study, 300 adults with DN will be recruited over 3 years. Following screening and baseline metabolic evaluations, eligible subjects will be treated with fenofibrate for 30-days and re-assessed. 4.1 Study Visits and Procedures Subjects will have their written

Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention

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As part of the central nervous system (CNS), the retina shares key structural and functional features with the brain, making it a potential portal into a patient's medical future. Since the cerebral and retinal microvasculature are strikingly similar, the condition of retinal vasculature has been

Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy

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Background of the Project including Preliminary Observations Hypertensive disorders of pregnancy, including preeclampsia, complicate up to 10% of pregnancies worldwide, constituting one of the greatest causes of fetal growth restriction, preterm birth, low birth weight, perinatal mortality, and

Study on Effect of Intestinal Microbiota Transplantation in Hepatitis B Virus Induced Cirrhosis

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A group of 60 patients with HBV induced cirrhosis will be recruited for study, which involved a 4 times IMT with gastroduodenoscopy and the time interval is generally 2 weeks. Participants can keep taking their present treatment. All participants will be assessed at baseline, after 3 months, 6

Evaluation of Fenugreek Seed Extract In Type- 2 Diabetes: An Add-On Study

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Diabetes mellitus is a complex heterogeneous group of metabolic conditions characterized by increased levels of blood glucose due to impairment in insulin action and/or insulin secretion. Diabetes is a condition primarily defined by the level of hyperglycemia giving rise to risk of microvascular

Examining the Immune Response in Patients With Gaucher Disease and Hepatitis C

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Gaucher disease is the most common glycolipid storage disorder, caused by reduced activity of the lysosomal enzyme glucocerebrosidase, which leads to the accumulation of the substrate, glucocerebroside (GC), in the cells of the reticulo-endothelial system. One of the hallmarks of GD is its great

Telmisartan Versus Losartan in Kidney Transplantation

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BACKGROUND In renal transplant recipients, residual renal insufficiency combined to the effects of immunosuppressive therapy with steroids or calcineurin inhibitors may reduce insulin activity and may contribute to several of the abnormalities associated with the metabolic syndrome, such as

Association Study of Genetic Polymorphisms of Candidate Genes With Thiazolidinedione-Related Peripheral Edema and Drug Responsiveness

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Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial

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Cardiovascular (CV) disease is the most common cause of morbidity and mortality among diabetic patients.The UK Prospective Diabetes Study (UKPDS)clearly showed that tight glycemic control significantly decreases diabetes-related events. Therefore, achievement of HbA1c < 7% is a major goal in the

Efficacy of Pioglitazone on Microcirculation in Type 2 Diabetes Patients Treated With Insulin

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Pioglitazone is a thiazolidinedione compound with a mode of action as a peroxisome proliferator-activated receptor gamma agonist. Activation of this receptor causes increased transcriptional activity at a number of locations that are important to carbohydrate and lipid (fat) metabolism. Insulin

Metformin in Amnestic Mild Cognitive Impairment

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The prevalence of Alzheimer's disease (AD) is expected to quadruple by the year 2047. There are no known curative or preventive measures for AD. Current treatment options for AD only address symptoms, and no treatments are available that focus on delaying the actual disease process. One of the

Comparative Trial Between 3 Types of Insulin Infusion Protocols

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I. RESEARCH OBJECTIVES AND SPECIFIC AIMS A. Introduction: Increasing evidence from observational studies in hospitalized patients with and without diabetes indicates that hyperglycemia is a predictor of poor outcome. Over the short-term, hyperglycemia can adversely affects fluid balance (through

Treatment of Refractory Diabetic Macular Edema With Infliximab

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Retinopathy affects on average 30% of all patients with diabetes. Good glycaemic control delays the onset and progression of retinopathy in subjects with both type 1 and type 2 diabetes. However, the incidence of retinopathy has not been declining in type 1 diabetes over the last decades, even if

Breast Cancer Lymphedema: Role of Insulin Resistance/FOXC2

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Lymphedema of the arm is an important, under-recognized, and under-treated complication of successful surgical and radiotherapeutic treatment of breast cancer. As a result of advances in early detection and effective adjuvant therapies, many women diagnosed with breast cancer today can expect

Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment

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This study is an eight-week, double-blind, placebo-controlled trial of rosiglitazone in schizophrenia subjects treated with clozapine using Bergman's Minimal Model Analysis (MINMOD) frequent sampled intravenous glucose tolerance test (FSIVGTT) for examination of glucose metabolism. Rosiglitazone,

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