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[Anti-allergic drugs inhibit the proliferation of bovine lens epithelial cells in culture].

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OBJECTIVE To examine the inhibitory effects of tranilast, ketotifen fumarate, and disodium cromoglycate which are used clinically as anti-allergic agents, on the growth of bovine lens epithelial cells (LE) in culture. METHODS LE was grown in Dulbecco's modified Eagle's medium(DMEM) with 10% fetal

Contact lens induced conjunctivitis: a model of human ocular inflammation.

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OBJECTIVE To demonstrate the usefulness of contact lens induced conjunctivitis as a model of human ocular inflammation and to evaluate the effect of antiallergic eyedrops on this model. METHODS We recruited 40 subjects with contact lens induced conjunctivitis. Half were treated with ketorolac

Novel polyvinyl pyrrolidone loaded olopatadine HCl laden doughnut contact lens to treat allergic conjunctivitis.

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Olopatadine HCl is an anti-allergic drug used for the management of allergic conjunctivitis. Currently, it is delivered via eye drop solution, which is highly inefficient due to low bioavailability. Silicone contact lenses can be used to sustain the release of ophthalmic drugs. However, the presence

Lens safety study with Picumast dihydrochloride--a double masked study using the Scheimpflug method.

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A double-masked study was performed to investigate a possible side effect of the antiallergic substance Picumast dihydrochloride on lens transparency. 372 patients with Picumast dihydrochloride- or Ketotifen-treatment regularly underwent ophthalmologic examinations and Scheimpflug photography of the

Adsorption of levocabastine eye drops by soft contact lenses and its effects in rabbit eyes.

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OBJECTIVE We evaluated the adsorption of levocabastine (LEV) eye drops onto soft contact lenses in rabbit eyes to confirm the safety of this antihistaminic and antiallergic agent. METHODS Low- and high- water-content soft contact lenses were placed on the eyes of three rabbits for each type of soft

Allergic conjunctivitis and contact lenses: experience with olopatadine hydrochloride 0.1% therapy.

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OBJECTIVE The efficacy of Patanol, a topically applied anti-allergic agent, was evaluated in a group of patients with allergic conjunctivitis due to contact lens wear (GROUP I) and a group comprised of seasonal allergic conjunctivitis patients, vernal conjunctivitis patients and atopic

Plumbagin Suppresses α-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity.

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Recent studies have shown that plumbagin has anti-inflammatory, anti-allergic, antibacterial, and anti-cancer activities; however, it has not yet been shown whether plumbagin suppresses alpha-melanocyte stimulating hormone (α-MSH)-induced melanin synthesis to prevent hyperpigmentation. In this

Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection.

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A 6-year-old Thai girl presented with itching, redness and copious discharge in both eyes. Slit-lamp biomicroscopy of the left eye revealed cobblestone papillae with marked ptosis while in the right eye only small papillae were observed. Punctuate epithelial keratitis was noted only in the left eye.

Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation.

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Ketotifen an anti-allergic drug delivered via eye drops has major limitations, including poor ocular bioavailability and poor patient compliance. The objective of the research work was to fabricate ketotifen loaded microemulsion laden hydrogels and silica shell nanoparticle-laden (prepared from

Chronic allergic conjunctivitis.

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Chronic allergic conjunctivitis (CAC) or perennial allergic conjunctivitis (PAC) is the most frequent form of allergy of the conjunctiva that is encountered in Northern Europe, particularly in city areas. Itching, redness of the mucosa, swelling of the lids and tearing are the main symptoms.

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