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15 resultados
Feline lens disorders.
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The lens is the second most powerful structure for refraction in the eye, and is important in the fine-focusing ability in individual species. Specific disorders of the feline lens are frequent in clinical practice and include: congenital anomalies, nuclear sclerosis, cataracts, lens subluxations
Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.
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We have developed a system using explanted embryonic chicken lens epithelia to express foreign recombinant genes containing crystallin DNA regulatory sequences introduced by calcium phosphate transfection. Optimal results were obtained with lens epithelia from 14-day embryos transfected 1 day after
Lens differentiation is controlled by the balance between PDGF and FGF signaling.
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How multiple receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated. We show here that the receptor for platelet-derived growth factor (PDGF) signaling recruits the p85 subunit of Phosphoinositide 3-kinase (PI3K) to regulate mammalian lens development. Activation of
The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species.
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OBJECTIVE
The purpose of this study was to determine in which species and under what conditions lens tumors occur.
METHODS
A review of databases of available human and veterinary ocular pathologic material and the previously reported literature.
METHODS
Approximately 18 000 patients who had ocular
Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.
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Transformation of cultured chick lens epithelial cells with a temperature-sensitive mutant of Rous sarcoma virus (tsRSV) leads to radical changes in cell shape and interactions. When cultured at the restrictive temperature (42 degrees C), the transformed cells largely retained epithelial morphology
Intraocular sarcomas in two rabbits.
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Intraocular neoplasms are described in 2 adult rabbits. The left globe of an 8-year-old male rabbit was enucleated after chronic inflammatory disease resulted in a nonvisual eye. The left globe of a 5-year-old female rabbit also was enucleated after a history of lens-induced uveitis, cataract
Telomerase activity with concurrent loss of cell cycle regulation in feline post-traumatic ocular sarcomas.
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Paraffin wax-embedded ocular globes of cats with post-traumatic ocular sarcomas were examined for the presence of TERT, the active subunit of telomerase. The latter is a ribonucleoprotein complex essential for immortalization and expressed by most malignant tumours, germ line cells, lens epithelial
Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique.
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UNASSIGNED
To report an innovative technique of interstitial brachytherapy developed for treatment of orbital soft tissue tumors.
UNASSIGNED
A 4-month-old child diagnosed with rhabdomyosarcoma of orbit was treated with multiagent chemotherapy (CTh) and brachytherapy. Pre-planning computed tomography
Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.
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Genome-wide CRISPR/Cas9 screens represent a powerful approach to studying mechanisms of drug action and resistance. Cereblon modulating agents (CMs) have recently emerged as candidates for therapeutic intervention in primary effusion lymphoma (PEL), a highly aggressive cancer caused by Kaposi's
Evidence for positive and negative regulation in the promoter of the chicken delta 1-crystallin gene.
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We investigated the role of sequences flanking the transcription initiation site of the delta 1-crystallin gene in transient transfection assays of primary embryonic chicken lens epithelial cells or fibroblasts. Varying lengths of the 5' flanking sequence of the delta 1-crystallin gene (containing
[Retinal lymphoma--simulating uveitis].
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A rare form of malignant large-cell non-Hodgkin's lymphoma or reticulum cell sarcoma is confined to the eye and central nervous system (CNS). We report the case of a 62-year-old man, who presented with recalcitrant progressive uveitis in his right eye. Although lymphoma was suspected, the patient
Comparative studies on antitumor activity of Klebsiella O3 lipopolysaccharide and its polysaccharide fraction in mice.
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The antitumor activity of the polysaccharide fraction (OPS) obtained by the acid hydrolysis of Klebsiella O3 lipopolysaccharide (KO3 LPS) isolated from the culture supernatant of the decapsulated mutant strain LEN-1 (03: K1-) against both allogeneic tumor and syngeneic tumor systems in mice was
Orbital extraskeletal osteosarcoma following enucleation in a cat: a case report.
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OBJECTIVE
We present a unique case of a feline orbital extraskeletal osteosarcoma that developed 5 years post-enucleation.
METHODS
In 2002, an ophthalmologist enucleated the left eye of a 2-year-old neutered male DSH and submitted it to the Comparative Ocular Pathology Laboratory of Wisconsin
The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.
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Adherens-type junctions (AJs) are major subcellular targets for tyrosine specific protein phosphorylation [Volberg et al. (1991) Cell Regul., 2, 105-120]. Here we report on the apparent effect of such phosphorylation events on the assembly and integrity of AJs. We show that incubation of MDCK cells
A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue.
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Mel-CAM (also termed CD146 or MUC18) is a cell-adhesion molecule belonging to the immunoglobulin gene superfamily. It mediates cell-cell interaction through heterophilic Mel-CAM/ligand adhesion. Previous studies showed Mel-CAM immunoreactivity in normal and neoplastic human tissues, but an extensive
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