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Página 1 a partir de 87 resultados
Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients.
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BACKGROUND
Epidemiological studies have established that a low serum concentration of carotenoids was associated with risk of Age-Related Macular Degeneration (ARMD). The aim of this study was to determine carotenoid levels in serum and in different lipoprotein fractions in patients diagnosed for
Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway.
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Intervertebral disc degeneration (IDD) is a main cause of diseases such as discogenic low back pain, cervical and lumbar disc herniation, degenerative spinal stenosis, and lumbar spondylolisthesis. Nuclear factor erythroid 2-related factor 2 (Nrf2), an important transcription factor, regulates
Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration.
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Carotenoids, in particular astaxanthin, possess potent antioxidant capabilities. Astaxanthin also induces NF-E2-related factor 2 (Nrf2), which plays a major regulatory role in the antioxidative response. However, little is known whether the carotenoid, by-products of astaxanthin, activate Nrf2.
Direct observation of a dark state in lycopene using pump-DFWM.
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We apply pump-degenerate four-wave-mixing (pump-DFWM) for the investigation of the ultrafast internal relaxation of the excited states of lycopene. A unique feature in the pump-DFWM signal, appearing at small temporal delays between the initial pump pulse and the DFWM sequence, provides direct
Mapping multidimensional excited state dynamics using pump-impulsive-vibrational-spectroscopy and pump-degenerate-four-wave-mixing.
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Pump-impulsive vibrational spectroscopy (pump-IVS) is used to record excited state vibrational dynamics following photoexcitation of two carotenoids, β-carotene and lycopene, with <30 fs temporal resolution, and covering the full vibrational spectrum of the investigated chromophores. The results
Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats.
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Deltamethrin is globally used in crop protection and control of malaria and other vector-borne diseases. It has a potent insecticidal activity with an appreciable safety margin. However, a number of studies have demonstrated nephrotoxicity of deltamethrin in mammalian and nonmammalian species.
Serum antioxidants and age-related macular degeneration among older Japanese.
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From the perspective of human nutrition, the prevention of age-related macular degeneration (AMD) through diet control is feasible and desirable. We investigated the relationship between serum antioxidants and AMD in the community-dwelling older Japanese eating a typical Japanese diet. In this
Serum carotenoids and risk of age-related macular degeneration in a chinese population sample.
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OBJECTIVE
It has been hypothesized that the macular carotenoids protect against age-related macular degeneration (AMD). In this study, the association between serum concentrations of carotenoids and the presence of AMD was evaluated in a case-control sample of elderly Chinese subjects.
METHODS
Two
Serum antioxidants and age-related macular degeneration in a population-based case-control study.
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OBJECTIVE
To investigate relationships between levels of tocopherols and carotenoids in the serum and age-related macular degeneration (ARMD).
METHODS
A nested case-control study within a population-based cohort.
METHODS
Cases included a sample of subjects with retinal pigment abnormalities with the
Protective effect of lycopene against mercury-induced cytotoxicity in albino mice: pathological evaluation.
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The present study was carried out to evaluate the protective role of lycopene on cytotoxicity induced by mercury in albino mice. The animals were randomly divided into seven groups. Group I (control) were treated with tap water Group II (positive control) were treated with 20 mg kg(-1) d(-1)
Rancidity development of refrigerated rainbow trout (Oncorhynchus mykiss) fillets: comparative effects of in vivo and in vitro lycopene.
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BACKGROUND
The problem of lipid oxidation in fish during storage is well known and is related to both temperature and storage time. Antioxidants could have a main role in limiting the deteriorative effects of lipid oxidation in fish. The present study aimed to investigate the effect of dietary
Lycopene prevents DEHP-induced liver lipid metabolism disorder by inhibiting HIF-1α-induced PPARα/PPARγ/FXR/LXR system
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Di-(2-ethylhexyl) phthalate (DEHP) is a widespread pollutant that badly affects animals and human health. Lycopene (LYC) has been used as a dietary supplement that has effective antioxidant and anti-obesity functions. The present goal was to understand the molecular mechanisms of LYC preventing
Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells.
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OBJECTIVE
Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in elderly people. The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelium (RPE) cells. Lycopene, a carotenoid, has been shown to possess
Intake of tomato-enriched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons.
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There is extensive evidence that oxidative damage of dopamine (DA)-containing neurons in the substantia nigra pars compacta (SNc) may contribute to the pathogenesis of Parkinson's disease (PD). We evaluated the potential neuroprotective effect of diets enriched with wild-type Red Setter (RS) tomato
Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin.
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Lycopene, lutein, and zeaxanthin are major carotenoids in human blood and tissues but unlike beta-carotene do not contribute to vitamin A supply. These carotenoids are efficient antioxidants quenching singlet molecular oxygen which is formed in photooxidative processes and thus may contribute to the
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