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lysergic acid/necrose
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The muscle findings in the neuroleptic malignant syndrome associated with lysergic acid diethylamide.
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A detailed pathological description of the muscle findings in a case of the neuroleptic malignant syndrome (NMS) following ingestion of lysergic acid diethylamide (LSD) is given, including the first ultrastructural analysis. Focal necrosis, oedema, and hypercontraction of fibres with glycogen and
Cytotoxicity and accumulation of ergot alkaloids in human primary cells.
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Ergot alkaloids are secondary metabolites produced by fungi of the species Claviceps. Toxic effects after consumption of contaminated grains are described since mediaeval times. Of the more than 40 known ergot alkaloids six are found predominantly. These are ergotamine, ergocornine, ergocryptine,
Muscle changes in the neuroleptic malignant syndrome.
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OBJECTIVE
To characterise the skeletal muscle changes in the neuroleptic malignant syndrome (NMS).
METHODS
Detailed light and ultrastructural examination was carried out on skeletal muscle from three cases of NMS, two associated with recreational drugs (3,4-methlenedioxymethylamphetamine (MDMA,
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