One intravenous injection of tranexamic acid. Total dose 1 gram (10mL)

One Injection of the placebo which is 10 mL Sodium Chloride (0.9%)

Intrapartum - Moderate and Severe Anaemia

Ampoules and packaging for both arms will be identical in appearance.

Tranexamic Acid

Placebo

Ayub Teaching Hospital

Bahawalpur Victoria Hospital

Aziz Bhatti Teaching Hospital

MCH PIMS

Military Hospital

Civil Hospital

Jinnah Postgraduate Medical Centre

Jinnah Hospital

Services Hospital

Sir Ganga Ram Hospital

Chandka SMBBMU Sheikh Zaid Woman Hospital

Nishtar Hospital

Bolan Medical Centre

Benazir Bhutto Shaheed Hospital

Federal Government Polyclinic

Holy Family Hospital

Women and Newborn Hospital

World Maternal Antifibrinolytic Trial_2

Tranexamic Acid for the Prevention of Postpartum Bleeding in Women With Anaemia: an International, Randomised, Double-blind, Placebo Controlled Trial.

Clinical assessment: This may be an estimated blood loss of more than 500 mL or any blood loss sufficient to compromise haemodynamic stability within 24 hours of delivery. Haemodynamic instability is based on clinical judgement and assessed using clinical signs (low systolic blood pressure, tachycardia, reduced urine output).

Any of the following: uterotonics, removal of placenta/placenta fragments, intrauterine balloon tamponade, bimanual uterine compression, external aortic compression, non-pneumatic anti-shock garments, uterine artery embolisation, uterine compression suture, hysterectomy and laparotomy to control bleeding

Any of the following:pulmonary embolism (PE), deep vein thrombosis (DVT), stroke, myocardial infarction

measured using Quality of life Questionnaire and walk test

Any of the following: Cardiovascular, Respiratory, Renal, Hepatic, Neurological, Coagulation/ haematologic dysfunction

diagnosis is based on the presence of both infection and a systemic inflammatory response syndrome (SIRS). SIRS requires two or more of the following: a) temperature <36°C or >38°C (b) heart rate >90 beats/min (c) respiratory rate >20 breaths/min (d) white blood cell count <4x109/L (<4000/mm³) or >12x109/L (>12,000/mm³)

Cause and time of death will be described

High Dependency and/or Intensive Care Units

Any untoward medical occurance (other than expected complications)

Data will be shared publicly when all planned analyses are completed by the Woman-2 Trial Collaborators. This will be hosted on freebird.lshtm.ac.uk

London School of Hygiene and Tropical Medicine

Wellcome Trust

Bill and Melinda Gates Foundation

A randomised, double blind, placebo controlled trial among 10,000 women with moderate or severe anaemia having given birth vaginally.

Masking was done by an independent clinical trials supply company. It will involve the removal of the original manufacturer's label and replacement with the clinical trial label bearing the randomisation number, which will be used as the pack identification. Apart from the randomisation number, all pack label texts will be identical for tranexamic acid and placebo.

Control group - patients with only levothyroxine therapy

Intervention Group- Patients with levocarnitine supplementation in addition to levothyroxine therapy

Patient Compliance

Levocarnitine syrup- Oral supplementation about 2000mg/ day for 8 weeks

Levocarnitine

Phamacology Department, BSMMU

Effect of Levocarnitine Supplementation for the Management of Fatigue in Levothyroxine-Treated Hypothyroid Patients

Dr. Farjana Akhter

Resident ( Phase-B)

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Control Group- Patients with only levothyroxine therapy Interventional Group- Patients with Levocarnitine supplementation in addition to levothyroxine therapy

patients receive one single dose of intravenous dexamethasone 8 mg.

patients receive one single dose of intravenous placebo.

Respiratory; Disorder, Functional, Impaired

One dose of intravenous dexamethasone (8 mg) 60 minutes before surgery.

Intravenous Dexamethasone

Patients of the control group received homologated placebo 60 minutes before surgery.

intravenous salin water

Research Unit in Clinical Epidemiology, Specialties Hospital. Mexican Institute of Social Security

Dexamethasone and Respiratory Function After Mastectomy

Effect of the Preoperative Administration of Dexamethasone in the Respiratory Function and Postoperative Symptoms in Women Undergoing Mastectomy for Cancer. Results of a Randomized Clinical Trial.

maximum amount of air a person can expel from the lungs after a maximum inhalation.

Measures the amount of air a person can exhale during a forced breath in one second.

An unpleasant sensation occurring in varying degrees of severity as a consequence of injury, disease, or emotional disorder.

Nausea is the feeling of having and urge to vomit. It is often called being sick to your stomach.

Vomiting is forcing the contents of the stomach up through the esophagus and out of the mouth.

Total dose of backup analgesic medication will be recorded during the last 24 hours after the surgical procedure.

Total dose of backup antiemetic medication will be recorded during the last 24 hours after the surgical procedure.

The prevalence of a disease in a particular percentage of the population; the number of cases of a particular disease per unit of population.

Determination of the oxygen saturation of arterial blood using an oximeter.

Alejandro Gonzalez-Ojeda

Alejandro González-Ojeda, Ph.D., M.D.

Instituto Mexicano del Seguro Social

2. Acetylcysteine group (NAC+S) , aside with the saline, patients will be given orally Acetylcysteine at a dose of 600 mg twice daily, on the day before and on the day of administration of the contrast agent.

Carnitine group (Car+S), aside with the saline, patients will be administrated with 20 mg/kg carnitine over 10 minutes 2 hours prior to the administration of the contrast agent and 8 hours after CT.

4. Phosphodiesterase type 5 inhibitor group (PDE5+S), aside with the saline patients will be given orally 20 mg tablets of PDE5 Tadalafil once daily 2 hours prior to the administration of the contrast agent and in the subsequent day.

Control group ( S ) , which will be treated without any extra agents, just Saline (0.9 %) will be given I.V. at a rate of 1 ml per kilogram of body weight per hour for 12 hours before and 12 hours after administration of the contrast agent.

Contrast Media Induced Nephropathy

to evaluate the effect of the above agents on Kidney functioning parameters

Acetylcysteine, Phosphodiesterase type 5 inhibitor ,Carnitine

Nazreth Hospital

Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN)

Potentially Nephroprotective Effects of Carnitine and Phosphodiesterase Type 5 (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN): A Double Blind Randomized Study

lysine/fadiga

World Maternal Antifibrinolytic Trial_2

Effect of Levocarnitine Supplementation for the Management of Fatigue in Levothyroxine-Treated Hypothyroid Patients

Dexamethasone and Respiratory Function After Mastectomy

Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN)

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