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6 resultados
The anti-tumor activity of Mikania micrantha aqueous extract in vitro and in vivo.
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Aqueous extract obtained from Mikania micrantha (MMAE) is commonly used as traditional medicine in some countries. We hypothesized that MMAE may inhibit tumor cell growth, both in an in vitro and in vivo setting. In in vitro experiments, two kinds of human cancer cell lines, K562 and Hela were used
Mikania laevigata: chemical characterization and selective cytotoxic activity of extracts on tumor cell lines.
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Cancer is the second major cause of mortality worldwide, losing only to cardiovascular disease. Nowadays, around 50% of antineoplastic drugs were discovered and isolated by indications of plants in folk medicine. In Brazilian flora there are many species of plants which have great therapeutic
Preparation, stereochemistry, and cytotoxic activity of the melampolides from Mikania minima.
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The semisyntheses of melampolides 1 and 2, previously found in Mikania minima, were carried out in order to confirm their chemical structures and to establish their absolute configurations. Their conformational analyses, performed using molecular mechanics, experimental (1)H NMR coupling constants,
Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenan-induced peritonitis.
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OBJECTIVE
The aim was to test the potential use of an extract of Mikania laevigata (popularly known in Brazil as guaco), made from leaves harvested in different months of the year, on neutrophil migration after an inflammatory stimulus and investigate the underlying molecular mechanisms.
METHODS
We
Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum.
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An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives,
Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation.
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The guaianolide 8-epi-mikanokryptin (1) and the melampolide 11Hβ-11,13-dihydromicrantholide (2) along with known sesquiterpene lactones (3-13) and other constituents were isolated from the aerial parts of different populations of Mikania micrantha and Mikania cordifolia collected in several states
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