Whole exome, genome wide and RNA sequencing

Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance

The aspirate sample obtained for research at the time a standard-of-care biopsy is taking place will be approximately 40cc. Bone marrow aspiration removes bone marrow fluid and cells through a needle placed into the bone. Usually this sample is taken from the back of the pelvic bone, but it may also be taken from the sternum or the front of the pelvic bone. A bone marrow biopsy removes bone with the marrow inside and is done prior to the aspirate. Each biopsy and aspirate procedure takes approximately 15 minutes total. Bone marrow aspirate may be collected in a separate tube for research or collected from the standard-of-care specimen with left-over aspirate not otherwise needed for clinical purposes, or from previous procedures.

Bone Marrow Aspirate and Biopsy

University of Iowa

Sleep Apnea in Patients With MGUS and MM

Melissa Bates

Assistant Professor

Department of Health and Human Services

Health Professionals Follow-up Study: a prospective cohort of male health professionals

Nurses' Health Study: a prospective cohort of female registered nurses

Plasma samples to analyze for insulin/IGF signaling, sex hormones and inflammatory response

Obesity

Lifelong Obesity

Cancer

There is no intervention. This is an observational study with trajectories of body fatness and diet as main exposure.

Trajectories of body fatness and diet

Diet, Adiposity, and Metabolic Alterations

Diet, Adiposity, and Metabolic Alterations: a Prospective Observational Study of Three US Cohorts

Plasma biomarkers of insulin/IGF signalling, including C-peptide, IGF-1, IGFBP-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio

Plasma estrone, estradiol, testosterone and sex hormone-binding globulin (SHBG)

Plasma CRP, IL-6, sTNFR2, adiponectin (total and HMW adiponectin), leptin and leptin receptor

De-identified IPD can be made available to other researchers upon request, following the guidelines for the collaboration of external researchers with the Nurses' Health Study and Health Professionals Follow-up Study

multiple myeloma/obesidade

Sleep Apnea in Patients With MGUS and MM

Diet, Adiposity, and Metabolic Alterations

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