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Transcranial Magnetic Stimulation (TMS) in Multiple Sclerosis

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It is based on the hypothesis that the application of transcranial magnetic stimulation (TMS) at 1 Hertz or 5 Hertz in patients with relapsing-remitting multiple sclerosis (RRMS) implies a neuroprotective effect against the progression of the disease, resulting in a clinical improvement (attenuation

Open Trail of γIFN for Friedreich Ataxia

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Friedreich ataxia (FRDA) is a devastating neurodegenerative disease that affects children and young adults. Patients become progressively unable to coordinate movements and walking until severe disability ensues. Most patients develop dilated cardiomyopathy and congestive heart failure. The disease

To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease

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This is a randomized open-label Phase 2 trial with parallel design using no-treatment group as control. Subjects in the treatment arm will receive subcutaneous G-CSF with the dosage of 10 microgram/kg/day, for 5 continuous days in the first week. The second dosage will be given in the 12 week. If

Central and Peripheral Nervous System Changes as Markers of Disease Progression in Multiple Sclerosis

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BACKGROUND Multiple Sclerosis (MS) is an autoimmune, inflammatory demyelinating disease targeting myelinated axons in the Central Nervous System (CNS). It is the most common nontraumatic cause of disability in young people. Most MS patients are diagnosed between the ages of 20 and 40 years. Denmark

Sleep Timing and Circadian Preferences in A Sample of Egyptian Patients With Hepatic Cirrhosis

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Cirrhosis of the liver is a chronic, diffuse, degenerative disease in which the parenchyma deteriorates, the lobules are infiltrated with fat and structurally altered, dense perilobular connective tissue forms and often areas of regeneration develop. These regeneration nodules have a reduced blood

High and Low Dose Carbidopa Treatment of Parkinson's Disease

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A. Specific Aims: Parkinson's disease is a common neurodegenerative disorder characterized by the progressive motor symptoms of tremor, rigidity, and bradykinesia. The prevalence is estimated at 102-109/100,000 and increases with age. It is the second most common neurodegenerative disorder after

Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized

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Assessing biomarkers in Alzheimer's disease and frontotemporal dementia 1. Specific Aims To enhance the field of biomarker recognition and facilitate preventative and personalized medicine we are now posing the following question, does the Israeli patient population present similar plasma protein

Plasma Exchange for Autoimmune Autonomic Failure

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Background: Until recently, it was thought that primary chronic autonomic failure occurring without central neurodegeneration (pure autonomic failure, PAF) reflected diffuse loss of catecholamine-producing cells (sympathetic noradrenergic nerves and adrenomedullary chromaffin cells) outside the

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