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paraproteinemias/albumina
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A case of monoclonal gammopathy of undetermined significance with abnormal low levels of plasma glycated albumin by M protein.
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BACKGROUND
It is known that an immunoglobulin abnormality affects various clinical laboratory measurements and leads to abnormal values. We experienced a case of monoclonal gammopathy of undetermined significance (MGUS) showing a falsely low plasma glycated albumin (GA) level.
METHODS
The patient
Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases.
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OBJECTIVE
Multiple myeloma is responsible for a wide variety of renal pathologies. Urinary protein and monoclonal spike cannot be used to diagnose cast nephropathy (CN). Because albuminuria is a hallmark of glomerular disease, this study evaluated the percentage of urinary albumin excretion (%UAE)
Metabolism of radio-iodinated human serum albumin in patients with monoclonal gammopathy.
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An immunological based study of monoclonal gammopathies among suspected individuals in Kashmir region.
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Serum and urine samples from 513 patients clinically suspected of monoclonal gammopathies over a period of five years (1992-97) were subjected to various immunological procedures viz, electrophoresis, immunoelectrophoresis and immunoglobulin estimations. Laboratory investigations confirmed
Gamma gap thresholds and HIV, hepatitis C, and monoclonal gammopathy.
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Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly.
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OBJECTIVE
To determine if there is an increased prevalence of monoclonal gammopathy in elderly blacks compared with whites, analogous to the difference in incidence of multiple myeloma reported for the two racial groups and to confirm age and gender relationships.
METHODS
Subjects were from the Duke
A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly.
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OBJECTIVE
To define the prevalence of monoclonal immunoglobulin (Ig) proteins and quantitative serum immunoglobulin levels in elderly Japanese in comparison with elderly Caucasians as possible factors related to the reported lower incidence of multiple myeloma in elderly Japanese than in elderly
Two-dimensional gel electrophoresis of serum specimens from patients with monoclonal gammopathies.
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We modified the ISO-DALT two-dimensional gel electrophoresis system to allow the routine examination of serum specimens from patients with monoclonal gammopathies. This system, MC-Iso 1, is characterized by a broad pH gradient for resolving the basic immunoglobulin heavy and light chains. The
Changing pattern of presentation in monoclonal gammopathy of undetermined significance: a single-center experience with 1400 patients.
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To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007). We observed a
Spectrum of monoclonal gammapathies in Andhra Pradesh.
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In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period of 1987 to 2000. The monoclonal band was identified in serum by agar gel electrophoresis in all the cases and in urine in a few cases. Characterization of paraprotein
Frequency of clonal dominance in the specific antibody response to DNP-HSA in CBA and C57BL mice reflects their susceptibility to age-associated development of monoclonal gammopathies.
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The effects of age, genetic background, and neonatal thymectomy on the levels and the heterogeneity of the specific antibody response were investigated in an experimental mouse model. Both intact and neonatally thymectomized (NTx) C57BL/KaLwRij (C57BL) and CBA/BrARij (CBA) mice were immunized at the
[Comparison of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma].
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OBJECTIVE
The study focuses on evaluation of differences in serum levels of selected biological indicators in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM), primarily from the viewpoint of potential asset to clinical practice.
METHODS
The analyse set of 96
[Contribution to the evaluation of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and in individual clinical stages of multiple myeloma].
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BACKGROUND
This study aimed to measure serum levels of 12 selected parameters in patients with monoclonal gammopathy of undetermined significance (MGUS) and initial, asymptomatic phase of multiple myeloma (MM) to assess their potential benefit in differentiating both conditions.
METHODS
The analysed
The physiopathological significance of benign monoclonal gammopathy: a study of 64 cases.
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Sixty-four patients with monoclonal protein in serum but initially without evidence of multiple myeloma, macroglobulinaemia, amyloidosis or lymphoma, were studied. Fifty patients (78%) were observed for a period of exceeding 3 years. Based on the follow-up data the patients were classified into the
Development of aging-associated monoclonal gammapathies with antibody activity to the antigen used for immunization of young mice.
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The influence of immunization with dinitrophenylated human serum albumin (DNP-HSA) at a young age on the development of age-related monoclonal gammapathies (MG) was investigated in a longitudinal study in intact and neonatally thymectomized (NTx) C57BL/KaLwRij and CBA/BrARij mice. Three-month-old
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