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Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot study.

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Xerostomia complaint is very commonly associated to radioactive iodine therapy. Alternatives to treat this morbidity can offer better quality of life to patients with thyroid cancer submitted to adjuvant iodine therapy. OBJECTIVE to report on the experience with pilocarpine on the treatment of

The effect of pilocarpine on the glaucomatous visual field.

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Patients with chronic open angle glaucoma are traditionally managed by medical therapy during the early stages of the disease. Pilocarpine is a well established topical agent, but suffers troublesome sequelae, the most apparent of which is pupillary constriction. This study assesses the effect of

The point on the ongoing B-cell depleting trials currently in progress over the world in primary Sjögren's syndrome.

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Conventionnal therapy (moisturizers, pilocarpine, Cevimeline, local Cyclosporine, and hydroxychloroquine) remains the basis for the treatment of primary Sjögren's syndrome (pSS) but they do not modify the course of the disease. Rituximab is currently the most fully evaluated biologics in pSS.

Long-term variability in short-wavelength automated perimetry compared to standard perimetry in glaucoma patients and normal subjects.

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OBJECTIVE To compare long-term variability (LTV) in short-wavelength automated perimetry (SWAP) with that of standard white-on-white (W-W) perimetry, in primary open angle glaucoma (POAG) patients and normal subjects and to determine its clinical significance. METHODS The sample comprised 30

QUANTITATIVE STUDIES OF PROSTATIC SECRETION : I. CHARACTERISTICS OF THE NORMAL SECRETION; THE INFLUENCE OF THYROID, SUPRARENAL, AND TESTIS EXTIRPATION AND ANDROGEN SUBSTITUTION ON THE PROSTATIC OUTPUT.

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A simple isolation of the prostate enabled quantitative collection of prostatic secretion in dogs over periods of months. The secretory stimulant was pilocarpine and 2 similar amounts injected with a 6 hour interval gave smaller amounts at the second testing, suggesting a fatigue effect. The

Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors.

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Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions or antagonism leave aspects of appetite and primary food motivation intact, rats with impaired DA transmission

Current and potential treatments for primary Sjögren's syndrome.

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A precise definition of primary Sjögren's syndrome resting on 'revised' or 'international' criteria has been accepted by most experts. This is important because the symptoms of primary Sjögren's syndrome, namely, dryness, fatigue, and pain, are common in the population at large and can occur in the

Update in Sjögren syndrome.

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Sjögren syndrome (SS), the second most common autoimmune rheumatic disease, refers to keratoconjunctivitis sicca and xerostomia resulting from immune lymphocytes that infiltrate the lacrimal and salivary glands. However, differential diagnosis remains confusing due to the high prevalence of vague

Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions.

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BACKGROUND Primary Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by sicca features and systemic manifestations, and requires a multidisciplinary therapeutic approach. METHODS Treatment of sicca manifestations is symptomatic and is based on the administration of topical

Treatment of primary Sjögren syndrome: a systematic review.

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BACKGROUND A variety of topical and systemic drugs are available to treat primary Sjögren syndrome, although no evidence-based therapeutic guidelines are currently available. OBJECTIVE To summarize evidence on primary Sjögren syndrome drug therapy from randomized controlled trials. METHODS We

Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.

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To evaluate current evidence on the efficacy and safety of topical and systemic medications in patients with primary Sjögren syndrome (SjS) to inform European League Against Rheumatism treatment recommendations.The MEDLINE, EMBASE and Cochrane databases

EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.

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The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European

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