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quinine sulfate/obesidade

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Taste preference in obese mice was examined using genetically obese (bombesin receptor subtype-3: BRS-3 deficient) animals. Preference for either sodium saccharin (0.2%). sodium chloride (0.9%), citric acid (0.1%), or quinine sulfate (0.002%) solution was examined using a two-bottle test situation,

Active regulation to be lean by rats with ventromedial hypothalamic lesions.

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Adult female Long-Evans rats with direct-current electrolytic or radio-frequency thermocoagulatory lesions of the ventromedial hypothalamus (VMH) lived on pellet fragments or a powdered chow containing as much as 1.2% quinine sulfate by weight or lived in Skinner boxes with 45-mg Noyes pellets

Rats defend different body weights depending on palatability and accessibility of their food.

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Normal adult rats lived on powdered diets adulterated to contain as much as 1.6% quinine sulfate, on a palatable high-fat diet, or in Skinner boxes with 45-mg Noyes pellets available on fixed-ratio (FR) schedules as high as FR 156. They maintained lower body weights over periods of months in
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