Wild-Type Quailes Strain Salmonella Typhi: Quailes Typhoid toxin knock out strain in a 1:1 ratio at a dose of 1-5 x 10^4CFU
All participants will receive the same intervention in a given group for challenge (dose reduction may occur for later participants depending on the results from the first six participants)

Salmonella Typhi Infection

The challenge agents will be delivered in 30 ml of sodium bicarbonate solution, preceded by 120 ml of solution of sodium bicarbonate to neutralise gastric acid.

Salmonella Typhi challenge

Centre for Clinical Vaccinology and Tropical Medicine (CCVTM)

Understanding How Salmonella Typhi Infects Humans (Bottlenecks)

Exploring the Bottleneck Hypothesis of the Pathogenesis of Bacteraemia in an Ambulatory Outpatient Human Experimental Infection of Salmonella Typhi

Number of participants with a bacteraemia caused by wild-type S. Typhi or Typhoid toxin knock-out strain or a combination of both strains as assessed by identification of strains isolated from blood cultures

Number of isolates that are wild-type S.Typhi or Typhoid toxin knock-out strain obtained using quantitative blood cultures

Number of participants with positive stool cultures caused by wild-type S. Typhi or Typhoid toxin knock-out strain or a combination of both strains as assessed by identification of strains isolated from stool cultures

Number of participants with a bacteraemia caused by wild-type S. Typhi or Typhoid toxin knock-out strain or a combination of both strains as assessed by identification of strains isolated from blood cultures (obtained at less than 72 hours post challenge)

To count what proportion of stool culture isolates are wild-type S.Typhi or Typhoid toxin knock-out strain obtained using quantitative stool cultures

Number of responses obtained from each recruitment method used and number of responses which translated into participants. Number of participants excluded and reasons for exclusion.

Direct access will be granted to authorised representatives from the Sponsor and host institution and the regulatory authorities to permit trial-related monitoring, audits and inspections.

salmonella infections/cefaleia

Understanding How Salmonella Typhi Infects Humans (Bottlenecks)

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