Celiac Disease in Children

Celiac Disease

Celiac

Disclosure

Stigma, Social

Emotional Problem

Mental Health Wellness 1

Semi-structured, face-to-face interviews will be carried out with participants.

semi-structured interview

Oxford University Hospitals Nhs Foundation Trust

Experiences of Disclosure in Adolescents With Coeliac Disease

Understanding Perceived Barriers to the Disclosure of Psychological Difficulties by Young People With Coeliac Disease

Includes questions around experiences of having coeliac disease and experiences of disclosing psychological difficulties to clinicians in the service.

Data will be kept for 5 years, separately to any identifiable information, and will then be disposed of securely. This is in accordance with Trust policy. The interviews will be deleted when the research study is finished.

University of Oxford

serum IgA-tissue transglutaminase antibody (tTG) was analyzed in serum using a quantitative automated ELISA method by means of a commercially available detection kit using recombinant human tTG as antigen recommended cut-off by the manufacturer > 8 U/mL).

upper gastrointestinal endoscopic examination will be done and the jejunal histopathological examinations will be done at the Histopathology Laboratory. The features consistent with CD included: hyperplasia of crypts, atrophy of villous, and increase of intraepithelial lymphocytes.Duodenal samples will be processed using haematoxylin/eosin staining and CD3 immunophenotyping. The number of intra-epithelial lymphocytes (IEL), the architecture of villi, and the inflammatory cell infiltration of the lamina propria will be assessed. Histopathological changes will be classified according to the Marsh-Oberhuber criteria.Lymphocytic enteropathy (Marsh 1 lesion) was defined as 25 or more IEL per 100 epithelial nuclei, and normal villous architecture.

Determination of anti-tissue transglutaminase IgA antibodies serum level.

anti-tissue transglutaminase group

Intestinal biopsy for histopathology study the jejunal histopathological

biopsy group

Anti-Tissue Transglutaminase IgA Antibodies

The Diagnostic Performance of Anti-Tissue Transglutaminase IgA Antibodies Serum Level for Detection of Patients With Celiac Disease

tTG are regarded as qualitative, i.e., positive or negative.Values of tTG between 2 and 7 U/mL will be considered as doubtful positive, and those of 7 U/mL or more as positive.
cut-off of ≥7 U/mL will be used in this study.

Suzan Alaa Babran

principal Investigator

Assiut University

All participants will receive the same, open-label dose of AGY

All participants will receive the same, open-label dose of AGY
AGY: AGY is a natural health product produced in egg yolks

AGY: Anti-gliadin Antibody for Celiac Disease

Sex: Female, Male

Race/Ethnicity, Customized

Region of Enrollment

Measures include: adverse events, serious adverse events, withdrawal due to adverse events, abnormal lab results

Number of Participants for Which Treatment Was Concluded to be Safe

Symptoms of Celiac disease will be self-measured by participants daily for the entire 6 week study period using the Celiac Symptom Index tool.

Number Celiac Disease Related Symptoms in Participants

health related quality of life will be measured at 4 time points using a validated tool; (short form 36; SF-36) baseline, week 2, week 4, and at the end of the study at week 6.
Scores can range from 20-80, with 50 being a population norm. Therefore, a score above 50 indicates better than the general population norm, and a score below 50 indicates worse than the population norm.

Health Related Quality of Life

The ATG antibody level will be measured at baseline, week 2, week 4 and week 6. Normal values are less than 7; elevated values mean a worse outcome. Assessed at baseline, week 2, week 4 and week 6; baseline and week 6 reported.

ATG Antibody Level

Overall Study

Dory Sample

AGY is a natural health product produced in egg yolks

University of Alberta

Oral AGY for Celiac Disease

Use of an Orally Administered Antibody to Gluten to Prevent the Recurrence of Symptoms and Laboratory Parameters in Persons With Celiac Disease (Gluten Sensitive Enteropathy)

Igy Inc.

All participants received open label AGY, a natural health product

Optimization of gluten introduction by nutritional councelling

No specific nutritional councelling. Follow-up of gluten introduction

Optimization of gluten introduction by nutritional counselling

Optimal gluten introduction

Kuopio University Hospital

Celiac Disease Prevention

Prevention of Celiac Disease in Children at Genetic Risk - Optimized Introduction of Gluten and Follow-up of Immunization

University of Eastern Finland

University of Turku

Finnish Institute for Health and Welfare

Päivikki and Sakari Sohlberg Foundation, Finland

Kätilöopisto Maternity Hospital

Atypical Depression

Escitalopram will be started at 10 mg per day and augmented weekly in 10 mg per day increments, the maximum dose being 20 mg per day. The dose will be titrated upward or downward based on clinical response and tolerability.

Escitalopram

Dept Psychiatry, Duke University Medical Center

Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features

A Pilot Study -- An Open-Label, Rater-blinded, Flexible-dose, 8-week Trial of Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features.

secale cereale/fadiga

Experiences of Disclosure in Adolescents With Coeliac Disease

Anti-Tissue Transglutaminase IgA Antibodies

Oral AGY for Celiac Disease

Celiac Disease Prevention

Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features

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