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6 resultados
Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens.
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Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been paid to protein tyrosine phosphatase 1B inhibitors as potential therapies for diabetes. The screening of a natural compound
Circular dichroism tests on the effect of alkali on conformation of lectins.
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The structural properties of eight lectins (agglutinins) were studied by the circular dichroism (CD) probe. The lectin from Maclura pomifera (osage orange seed) exhibited in the far-ultraviolet spectral zone a positive CD band centered at 201 nm, whereas the other lectins had positive bands at
Circular dichroism study on structural reorganization of lectins by sodium dodecyl sulfate.
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The circular dichroism (CD) spectra of lectins from Dolichos biflorus, Helix pomatia, Lotus tetragonolobus, Phaseolus vulgaris (erythroagglutinin), Pisum sativum, Sophora japonica, and Ulex europaeus I were analyzed, before and after the conformational transitions which were effected by sodium
Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress.
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Sophora species are used as dietary medicines in aging-associated symptoms. Sophora tomentosa L. (ST) is a native medicinal plant in Southeast Asia; however, there is no pharmacological literature about ST extract. The present study evaluates the antioxidant phytoconstituent contents and
Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens.
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It is well known that flavanones, sophoraflavanone G 1, kurarinone 2, and kurarinol 3, from the root of Sophora flavescens, have extremely strong tyrosinase inhibitory activity. This study delineates the principal pharmacological features of kurarinol 3 that lead to inhibition of the oxidation of
Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens.
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Tyrosinase is known for an enzyme that plays a key role in producing the initial precursor of melanin biosynthesis. Inhibition of the catalytic reaction of this enzyme led to some advantage such as skin-whitening and anti-insect agents. To find a natural compound with inhibitory activity towards
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