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5-HT(3) receptor antagonists.

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The 5-HT(3) receptor is a ligand-gated ion channel widely distributed in the central and peripheral nervous systems. Many selective 5-HT(3) receptor antagonists have been developed; animal studies with such compounds suggested their potential therapeutic value in combating emesis and a wide range of

[Spontaneous reports on unwanted drug effects in the years 1978-1979].

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In 1978/1979 the Medicines Commission of the German Medical Profession received 5196 spontaneous reports on adverse drug reaction (ADRs) from physicians, manufacturers, intensive hospital monitoring and pharmacists. The total number of ADRs reported by the physicians was 1867. The symptoms mostly

Post-gastrectomy problems in patients with personality defects: the "albatross" syndrome.

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Of a series of 130 patients undergoing operation for peptic ulcer disease at the Vancouver General Hospital, seven patients with personality defects had a disastrous outcome after operation.THE MAIN FEATURES OF THIS POSTGASTRECTOMY SYNDROME WERE REMARKABLY SIMILAR: persistent abdominal pain without

Overall safety profile and effectiveness of tramadol hydrochloride/acetaminophen in patients with chronic noncancer pain in Japanese real-world practice.

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OBJECTIVE To evaluate the overall safety profile and clinical effectiveness of tramadol hydrochloride/acetaminophen (TA) combination tablets in Japanese patients with chronic noncancer pain unrelieved by non-opioid drugs for up to 12 weeks in real-world practice. METHODS This survey was a

Use of Fentanyl Patch for Treatment of Moderate-to-severe Chronic Noncancer Pain: Postmarketing Surveillance of Medical Practice in Japan Using a Risk Minimization Action Plan.

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The purpose of this study was to discuss the safety, treatment profile, and clinical effectiveness of 12-month treatment with fentanyl patch (FP), a strong opioid, in medical practice in Japan under the risk minimization action plan (RMAP). Patients with moderate-to-severe chronic noncancer pain who

[Buprenorphine transdermal patch (Norspan tape)].

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Buprenorphine is a chemically synthesized opioid characterized as the partial mu agonist and kappa antagonist, and transdermal buprenorphine patch will be considered useful as a strong analgesic with fewer psychological side effects in the treatment of chronic non-cancer pain. Use of transdermal

[A peculiar variant of drive pathology in schizophrenia with the anorexia nervosa syndrome].

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Detailed clinical and psychological experimental study of 103 schizophrenia patients with anorexia nervosa revealed its most characteristic correlations with a specific variant of the pathology of drive--bulimia bouts and induced vomiting. This variant of the pathology of drive appeared to be

[Pharmacokinetics of PF-402, sustained-release morphine capsule, in cancer patients with pain].

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A once-daily dose of PF-402 60 mg and twice-daily doses of sustained-release morphine sulfate tablets (MSC) 30 mg were repeatedly administered in cancer patients in a cross-over design. Their plasma concentrations were measured, and the pharmacokinetics of PF-402 and MSC were compared. A total of 7

Anorexia nervosa at normal body weight!--The abnormal normal weight control syndrome.

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Disgust with "fatness" and a consequent preoccupation with body weight, coupled with an inability to reduce it to or sustain it at the desired low level, characterizes the abnormal normal weight control syndrome. Individuals remain sexually active in a biological sense and often also socially.

Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT3A receptors.

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Serotonin type 3 receptors (5-HT₃Rs) are cation-conducting pentameric ligand-gated ion channels and members of the Cys-loop superfamily in eukaryotes. 5-HT₃Rs are found in the peripheral and central nervous system, and they are targets for drugs used to treat anxiety, drug

Analysis of Consumption of Energy Drinks by a Group of Adolescent Athletes.

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Energy drinks (EDs) have become widely popular among young adults and, even more so, among adolescents. Increasingly, they are consumed by athletes, particularly those who have just begun their sporting career. Uncontrolled and high consumption of EDs, in addition to other sources of caffeine, may

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities.

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Human tissues express cannabinoid CB(1) and CB(2) receptors that can be activated by endogenously released 'endocannabinoids' or exogenously administered compounds in a manner that reduces the symptoms or opposes the underlying causes of several disorders in need of effective therapy. Three

Comparative efficacy and safety of analgesics for acute renal colic: A network meta-analysis protocol.

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Acute renal colic is one of the most common urological emergencies. While previous randomized controlled trials (RCTs) and pairwise meta-analyses only looked at the efficacy of 1 or 2 analgesics. It is not fully understood that the comprehensive ranking of the effectiveness and

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