tetrandrine/inflamação

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Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation.

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Targeting activated macrophages using anti-inflammatory phytopharmaceuticals has been proposed as general therapeutic approaches for rheumatic diseases. Besides macrophages, chondrocytes are another promising target of anti-inflammatory agents. Tetrandrine is a major bisbenzylisoquinoline alkaloid

Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor.

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The effects of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine on the action of IL-1, TNF and PAF were investigated in the rat subcutaneous air pouch model of inflammation. Both compounds were equipotent in the suppression of leukocyte infiltration into air pouches induced by IL-1 and

Reduction of the pro-inflammatory response by tetrandrine-loading poly(L-lactic acid) films in vitro and in vivo.

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Inflammatory response of implantable biomaterials and drug delivery vehicles, driven by the reaction of macrophages to foreign body particles released from the implant, is an urgent problem to resolve. Despite this, little is known about the inflammatory molecular mechanism following the

Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats.

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Two isoquinoline plant alkaloids, tetrandrine (1) and berbamine (2), have been evaluated for anti-inflammatory activity in an acute paw oedema assay and in adjuvant-induced arthritis in rats. 1 but not 2 suppressed the chronic inflammation in the arthritis model but neither compound was active in

Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats.

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OBJECTIVE To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure

Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor.

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Tetrandrine and berbamine are bisbenzylisoquinoline compounds which differ from each other in a minor way in terms of chemical structure, yet tetrandrine is 6-18 times more potent than berbamine in terms of inhibitory effects on production of interleukin-1 and tumor necrosis factor (TNF alpha) by

Anti-inflammatory and immunosuppressive properties of the bis-benzylisoquinolines: in vitro comparisons of tetrandrine and berbamine.

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Tetrandrine and berbamine are two naturally occurring analogues with a bis-benzylisoquinoline structure. Comparative in vitro studies show that tetrandrine has significantly greater suppressive effects on adherence, locomotion and 3H-deoxyglucose uptake of neutrophils, as well as the mitogen-induced

Evaluation of the novel anti-inflammatory agent tetrandrine as a pulpotomy medicament in a canine model.

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Tetrandrine, a bisbenzylisoquinoline alkaloid with unique broad-spectrum anti-inflammatory properties, was evaluated as a pulpotomy medicament in a canine model. Histological sections were evaluated after three days (acute inflammation) and six weeks (chronic inflammation) by two criteria: 1)

Inhibitory effect of tetrandrine on lens proteins-induced ocular inflammation in rabbits.

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Ocular inflammation was induced by 25 microliters of lens proteins (62.5mg/ml) injected into anterior chamber of the rabbit eye. Tetrandrine (Tet) (50mg/kg ip) and Indomethacin (Ind) (20 mg/kg ip) showed marked inhibition on this ocular inflammation. Maximum inhibition rate of Tet and Ind was 65%

Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions.

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We hypothesized that prevention of neutrophil from activation may underlie the myocardial protective effect of the specially processed extract of radix Stephaniae tetrandrae (SPRST). Inflammatory responses in isolated peripheral human neutrophils were studied in the presence or absence of SPRST.

Inhibitory effects of tetrandrine on angiogenesis in adjuvant-induced chronic inflammation and tube formation of vascular endothelial cells.

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The inhibitory effects of tetrandrine (an alkaloid isolated from the Chinese medicine Stephania tetrandrae S. Moore) were investigated in terms of the angiogenesis in an adjuvant-induced chronic inflammation model of mouse and tube formation of rat vascular endothelial cells (EC). Tetrandrine

Tetrandrine suppresses pro-inflammatory mediators in PMA plus A23187-induced HMC-1 cells.

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Tetrandrine (TET), a bis-benzylisoquinoline alkaloid from the root of Stephania tetrandra, is known to possess antitumor activity in various malignant neoplasms. However, the precise mechanism of TET-mediated immune modulation remains to be clarified. One of the possible mechanisms for its

Demonstration of the induction of apoptosis (programmed cell death) by tetrandrine, a novel anti-inflammatory agent.

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Tetrandrine, a bisbenzylisoquinoline alkaloid, was found to cause death of malignant lymphoid and myeloid cells but not of Epstein-Barr virus-transformed lymphoblastoid cells. The death took the form of apoptosis (programmed cell death), the nature of the process being confirmed by DNA gel

[Effects of tetrandrine on vascular permeability and neutrophil function in acute inflammation].

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The effects of tetrandrine (Tet) on vascular permeability and neutrophil (Neu) functions in carrageenin induced subcutaneous air pouch inflammation in rats were studied. It was found that the vascular permeability, Neu emigration, beta-glucuronidase (beta-G) release and superoxide anion (O2-)

Anti-inflammatory effects of fangchinoline and tetrandrine.

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Fangchinoline and tetrandrine are the major alkaloids from Stephania tetrandrae S. Moore which has been used traditionally for the treatment of inflammatory diseases in oriental countries including Korea. Both fangchinoline and tetrandrine showed anti-inflammatory effects on mouse ear edema induced

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