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Impact of seasons and dioecy on therapeutic phytoconstituents of Tinospora cordifolia, a Rasayana drug.

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Tinospora cordifolia (Thunb.) Miers, Menispermaceae, is a dioecious creeper, commonly known as "Giloe" or "Guduchi" with significant medicinal importance in the traditional systems of medicine. It is designated as Rasayana drug in Ayurveda and recommended for a number of diseases and also as

Validation of therapeutic claims of Tinospora cordifolia: a review.

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This review article attempts to correlate Ayurvedic pharmacology and therapeutic claims for Tinospora cordifolia (Tc) with the evidence generated using scientific research methodology. In the present paper, a brief description of Ayurvedic pharmacology of the plant is presented. The work carried out

Immunomodulatory and therapeutic potentials of herbal, traditional/indigenous and ethnoveterinary medicines.

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Herbs/Botanical plants are considered as God's gift to human beings in the form of natural medicines, like the one well known "Sanjeevani booti" described in Hindu Mythology. The traditional and ethno-veterinary practices have been in use for centuries, transferring the knowledge from generation to

Tinospora cordifolia aqueous extract alleviates cyclophosphamide-induced immune suppression, toxicity and systemic candidiasis in immunosuppressed mice: In vivo study in comparison to antifungal drug fluconazole.

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The present study was aimed to evaluate the effect of an aqueous extract of Tinospora cordifolia (AETC) against cyclophosphamide (CYP)-induced immunesuppression and systemic candidiasis in a murine model.Mice injected with a single dose of CYP (200 mg/kg)

Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis.

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Enhancement of the diseased mammary gland immunity and therapeutic potential of hydro-methanolic extract of Tinospora cordifolia (T. cordifolia; stem) in bovine subclinical mastitis was investigated. Somatic cell count (SCC), total bacterial count (TBC), phagocytic activity, and leukocyte lysosomal

Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis.

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The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The

Tinospora Cordifolia Induces Cell Cycle Arrest in Human Oral Squamous Cell Carcinoma Cells.

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Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. Tinospora cordifolia (Guduchi) has been used for centuries in Ayurvedic system of medicine for treating various ailments including

Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT -MS/MS.

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BACKGROUND The stem of dioecious Tinospora cordifolia (Menispermaceae) is a commonly used traditional Ayurvedic medicine in India having several therapeutic properties. OBJECTIVE To develop and validate LC-MS methods for the identification and simultaneous quantitation of various secondary

Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia.

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OBJECTIVE Diabetes during pregnancy increases the incidences of congenital anomalies, morbidity, and mortality in the mother and her fetus/newborn. Oxidative stress (OS) has been implicated to be responsible because various antioxidants have been demonstrated to be beneficial in diabetic

Tinospora tuberculata suppresses nitric oxide synthesis in mouse macrophages.

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We have obtained evidence that co-incubation of thioglycollate-elicited peritoneal macrophages with an aqueous extract of Tinospora tuberculata inhibits lipopolysaccharide-stimulated excessive production of nitric oxide (NO) in vitro. This effect is concentration-dependent and appears to involve

PRELIMINARY INVESTIGATION OF NORMOGLYCEMIC, ANTI-HYPERGLYCEMIC AND DYSLIPIDEMIC ACTIVITIES OF DIFFERENT EXTRACTS OF TINOSPORA CRISPA ON DIABETIC RAT.

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Tinospora crispa is an indigenous medicinal plant belonging to Menispermaceae family, known localy as "akar patawali" or as "akar seruntum". Different parts of this plant are used for various therapeutic purposes for treatment of hypertension, stimulation of appetite, protection from mosquito bites

Endophytic fungi of Tinospora cordifolia with anti-gout properties.

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Targeting xanthine oxidase inhibition has been a prime strategy for exploration and development of non-purine based drugs for anti-hyperuricemic therapy. Recent studies from our laboratory have suggested that fungal endophytes from medicinal plants could play a pivotal role in exploration of novel

Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice.

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The present study was taken up to investigate the effect of petroleum ether extract of Tinospora cordifolia (Wild.) Miers, on depression in mice. The extract (50, 100 and 200 mg/kg, p.o.) was administered for 14 successive days to Swiss young albino mice (either sex) and evaluated for

Seasonal variations in physicochemical profiles of Guduchi Satva (starchy substance from Tinospora cordifolia [Willd.] Miers).

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Guduchi Satva (GS), the starchy material extracted from the Guduchi stem is well-known Ayurvedic single drug formulation having a wide range of therapeutic utility. Species of the plant, stem size, collection time, season and maturity of the plant may affect the yield and physico-chemical profile of

Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments

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Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle

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