topotecan/edema

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Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment.

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OBJECTIVE To determine intravitreal and plasma concentrations and retinal toxicity after transcorneal intravitreal injection of 1 μg and 2 μg of topotecan (Hycamtin). METHODS Twelve healthy albino rabbits were included in this in vivo experiment. Six anesthetized albino rabbits received a single

Recurrent encephaloclastic cyst induced by intraventricular topotecan.

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OBJECTIVE To report two rare cases of encephaloclastic cyst induced by intraventricular topotecan. To share our experience in diagnosing and treating this rare disease. BACKGROUND Ommaya reservoirs provide fast access and reliable drug delivery to cerebral spinal fluid. They are routinely utilized

A phase I study of periocular topotecan in children with intraocular retinoblastoma.

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OBJECTIVE To identify the maximum tolerated dose and dose-limiting toxicity of periocular topotecan in patients with relapsed or resistant intraocular retinoblastoma who are facing imminent enucleation. METHODS For this phase I study, a starting dose of 0.5 mg of periocular topotecan administered

A phase 1b study of trebananib in combination with pegylated liposomal doxorubicin or topotecan in women with recurrent platinum-resistant or partially platinum-sensitive ovarian cancer.

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OBJECTIVE To examine the tolerability and antitumor activity of trebananib plus pegylated liposomal doxorubicin (PLD) or topotecan in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer. METHODS In this open-label phase 1b study, patients received trebananib 10 mg/kg or 15

Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children.

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Convection-enhanced delivery (CED) for the treatment of malignant gliomas is a technique that can deliver chemotherapeutic agents directly into the tumor and the surrounding interstitium through sustained, low-grade positive-pressure infusion. This allows for high local concentrations of drug within

Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma.

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BACKGROUND Treatment of eyes with retinoblastoma failing systemic chemoreduction and external beam radiotherapy is seldom efficacious. This study compares the efficacy and toxicity of intra-arterial ophthalmic artery chemotherapy (IAO) to our historical cohort of sequential periocular and systemic

Chemotherapy-induced posterior reversible encephalopathy syndrome: Three case reports.

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Posterior reversible encephalopathy syndrome (PRES) has been associated with the use of several medications, including chemotherapeutic agents.A 65-year-old woman was diagnosed with adenocarcinoma of the ovary, after sixth-line treatment with topotecan, at

Rabbit Model of Intra-Arterial Chemotherapy Toxicity Demonstrates Retinopathy and Vasculopathy Related to Drug and Dose, Not Procedure or Approach.

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To use our intra-arterial chemotherapy (IAC) rabbit model to assess the impact of IAC procedure, drug, dose, and choice of technique on ocular structure and function, to study the nature and etiology of IAC toxicity, and to compare to observations in

INTRAVITREOUS CHEMOTHERAPY FOR ACTIVE VITREOUS SEEDING FROM RETINOBLASTOMA: Outcomes After 192 Consecutive Injections. The 2015 Howard Naquin Lecture.

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OBJECTIVE To investigate on the safety and efficacy of intravitreous chemotherapy for retinoblastoma seeding in a relatively large cohort and provide information on the necessary number of injections and long-term control. METHODS Retrospective interventional case series of 40 consecutive eyes with

Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).

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OBJECTIVE To report on our 3-year experience with the use of superselective ophthalmic artery infusion of chemotherapy as initial, primary treatment for intraocular retinoblastoma. METHODS Prospective, institutional review board-approved clinical trial. METHODS Twenty-eight eyes of 23 newly

Intra-arterial chemotherapy as second-line treatment for advanced retinoblastoma: A 2-year single-center study in China.

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UNASSIGNED To evaluate the effectiveness and complications of intra-arterial chemotherapy (IAC) for treating advanced refractory retinoblastoma (RB) in a large single-center cohort. UNASSIGNED Eighty-four eyes of 62 consecutive patients with advanced refractory RB who received IAC were included in

Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina.

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BACKGROUND The feasibility and results of intraarterial chemotherapy, also termed ophthalmic artery chemosurgery (OAC), for retinoblastoma in less developed countries have seldom been reported. METHODS A retrospective evaluation of a program of OAC in Argentina from 2010 to

Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma.

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OBJECTIVE To analyze our 5-year experience of intra-arterial chemotherapy (IAC) for retinoblastoma as primary or secondary therapy. METHODS Retrospective interventional case series. METHODS A total of 70 eyes of 67 patients. METHODS Ophthalmic artery chemotherapy infusion under fluoroscopic guidance

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