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Androgenization: alterations in the mechansim of oestrogen action.
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Total nuclear uptake of oestradiol, specific nuclear binding of oestradiol and oestrogen-induced proteins were studied in the uterus of femal Sprague-Dawley rats injected on postnatal day 3 with sesame oil or with 1-25 mg of testosterone propionate in sesame oil (androgenization). Total uptake of
Effect of neonatal androgenization on the testosterone feedback sensitivity in adult rats in two lighting conditions.
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Neonatally androgenized and intact adult male Wistar rats received daily, during 1 week, either testosterone propionate or sesame oil injections in periodic or constant light. Serum and pituitary gonadotropins and hypothalamic LHRH were measured. In periodic light, neonatal androgenization did not
Reduced extracellular levels of serotonin in the amygdala of androgenized female rats.
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The object of this study was to evaluate the effect of androgenization on the extracellular concentrations of serotonin in the amygdala of otherwise intact female rats. One group of animals received one high dose of testosterone (1 mg, s.c.) within three hours after birth, one group received
Effects of perinatal Kepone exposure on sexual differentiation of the rat brain.
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Timed-pregnant Sprague-Dawley rats were injected intraperitonealy with Kepone dissolved in sesame oil on alternate days beginning on day 18 of gestation and extending through day 7 of lactation with doses of 10 or 5 mg/kg. At 7 days of age the neurologic development of the pups was assessed using
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