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Two natural products isolated from the plant Daphne genkwa have been shown to possess antileukemic activity in mice. Genkwadaphnin and yuanhuacine were observed to inhibit DNA and protein synthesis in P-388 leukemic cells. A detailed study of the effects of these two diterpene esters on protein
The diterpene esters, genkwadaphnin and yuanhuacine, have been shown to possess significant antileukemic activity in the P-388 screen. The major metabolic effects of the diterpene esters were on DNA and protein synthesis. The effects on DNA synthesis in vitro were evoked at a lower concentration
This review presents seven examples of effective drugs derived from the ancient Chinese therapeutics. They are artemisinin (qinghaosu) and its derivatives for malaria, henbane drugs for microcirculatory and other disturbances, tetrahydropalmatine as a dopamine receptor antagonist, yuanhuacine and