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Gastrointestinal protective efficacy of Kolaviron (a bi-flavonoid from Garcinia kola) following a single administration of sodium arsenite in rats: Biochemical and histopathological studies.
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BACKGROUND
Arsenic intoxication is known to produce symptoms including diarrhea and vomiting, which are indications of gastrointestinal dysfunction.
OBJECTIVE
We investigated whether Kolaviron (KV) administration protected against sodium arsenite (NaAsO2)-induced damage to gastric and intestinal
Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53.
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Cisplatin, an antineoplastic drug, is widely used as a foremost therapy against numerous forms of cancer but it has pronounced adverse effects viz., nephrotoxicity, ototoxicity etc. CDDP-induced emesis and diarrhea are also marked toxicities that may be due to intestinal injury. Chrysin
Preparation of an oil suspension containing ondansetron hydrochloride as a sustained release parenteral formulation.
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Ondansetron hydrochloride (ODS) is a selective 5-hydroxytryptamine type 3 antagonist for nausea and emesis prevention in neoplastic patients. To reduce dosing frequency and side effects and improve patient compliance, a sustained release parenteral formulation of ODS was developed. Microparticles of
Effect of diet on T-2 toxicosis.
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T-2 toxin is an emetic trichothecene mycotoxin produced by Fusarium molds. This compound causes feed refusal, emesis and lesions in the gastrointestinal tract of livestock, poultry and man. Studies in our laboratory have indicated that the feeding of high fibre diets, non-nutritive mineral additives
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