[Endogenous sex hormone testosterone and haemostatic factors in young men after myocardial infarction].
Cuvinte cheie
Abstract
OBJECTIVE
To compare levels of haemostatic factors and sex hormones in young men after myocardial infarction, to study relationship between sex hormones and factors of hemostasis.
METHODS
We studied 32 men aged 30-50 years with diagnosis of myocardial infarction. Patients were divided into 2 groups according to age: group 1 - 11 patients aged 30-39 years, group 2 - 21 patients aged of 40-50 years. Levels of sex hormones were measured by IFA. Level of fibrinogen, prothrombin index, plasma recalcification time, fibrinolytic activity, indices of aggregation and disaggregation were also determined.
RESULTS
Testosterone level in the group I was more decreased in comparison with the Group 2 and level of fibrinogen was higher in the group 1 (3.9+/-0,7) in comparison with the group II (3.1+/-0.8; p<0.05). Pearsons correlation between estradiol and fibrinogen in the group 1 was 0.613 (p<0.05). No such relationship was found in the group 2. Pearsons correlation between testosterone and prothrombin index was 0,477 (p<0.009).
CONCLUSIONS
Endogenous testosterone level is one of the factors which influence haemostatic system, but this effect is not well-defined and requires further study.
