Weight Loss

Belviq Tablet® Post Marketing Surveillance Protocol

Any adverse events occurred after this drug dosing will be recorded. Description of adverse event(s) including type of adverse event(s), onset/end date, severity, action taken, causal relationship to the drug and investigator's view on the adverse event(s) will be captured, whether it is related to the drug or not and until follow up visit more than 1 time during the surveillance period.
Lab abnormalities and changes in vital signs are considered to be adverse events only if they result in discontinuation from the study, necessitate therapeutic medical intervention, and/or if the investigator considers them to be adverse events.

BMI is measured before administration of the drug and within 12 weeks after administration.

IlDong Pharmaceutical Co Ltd

patient will receive a fix dose of 75 μg of palonosetron

patient will receive a bodyweight-adjusted dose of 1mcg/kg of palonosetron

Postoperative Nausea and Vomiting

receive a fix dose of 75 μg of palonosetron (group I - GI) and another forty patients will receive a bodyweight-adjusted dose of 1mcg/kg of palonosetron (group II - GII).

palonosetron

National Cancer Institute (INCA - HCIII)

Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients

Comparative Study Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients Undergoing Breast Surgery

To determine the frequency of individual episodes of nausea and vomiting in the periods of 6 hours postoperatively

To determine the frequency of individual episodes of nausea and vomiting in the period of 24 hours postoperatively

Compare need of antiemetic rescue medication during the periods of 48 hours postoperatively

Determine the number of patients who had complete antiemetic response (absence of nausea, vomiting and need for rescue medication)

To determine the frequency of individual episodes of nausea and vomiting in the periods of 48 hours postoperatively

To evaluate the frequency of polymorphism of the 5-HT3 receptors and their correlation with the antiemetic effect and adverse effects

Even if this data is used for scientific publication, patient identification will remain secret

Nathalia Ferreira

Anesthesiologist. MSc student of Department of Anesthesiology of Federal University of Rio de Janeiro, Brazil.

Instituto Nacional de Cancer, Brazil

A Very Low Carbohydrate Diet was administered for four weeks. VLCD = <20g/day of carbohydrates

Four Week Very Low Carbohydrate Diet

Sex: Female, Male

Region of Enrollment

Adequate relief was measured as the primary endpoint via a single item Adequate Relief Question asking "Over the past week have you had adequate relief of your symptom experience". Higher scores represent greater levels of adequate relief over the week prior to the assessment. Participants completed this 1-item questionnaire at the end of each of weeks of the study, assessing whether they had adequate relief of their IBS symptoms for the week.
A responder was defined as reporting adequate relief in at least 2 of the 4 weeks on the VLCD.

Number of Subjects Reporting "Adequate Relief" From IBS Symptoms for the Previous Week. Adequate Relief Was a "True/False" Item.

Stool Frequency was measured as number of stools per day

Impact of Very Low Carbohydrate Diet on Stool Frequency

Units of measurement on the Sickness Impact Profile were ordinal rated scored. Information on scoring use and interpretation of the Sickness Impact Profile, readers are encouraged to read Bergner et. al. 1981 - Bergner, M., Bobbit, R.A., Carter, W.B. et all (1981) the Sickness Impact Profile: Development and final revision of a health status measure. Medical Care, 19:787-805 The SIP measures sickness-related dysfunction based on behavior in order to provide a measure of health status that will aid in assessing the outcome of health care services.

Sickness Impact Profile

Two weeks of a carbohydrate rich diet was followed by four weeks of A Very Low Carbohydrate Diet. VLCD = <20g/day of carbohydrates

Standard Diet Then Very Low Carbohydrate Diet

Two Week Standard Diet

Stephan R. Weinland, Ph.D.

Diarrhea Predominant Irritable Bowel Syndrome

4 weeks on strictly controlled low carbohydrate diet

5 hydroxytryptamine/obezitate

Belviq Tablet® Post Marketing Surveillance Protocol

Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients

Effects of a Very Low Carbohydrate Diet on Symptoms of Irritable Bowel Syndrome (IBS)

Cea mai completă bază de date cu plante medicinale susținută de știință