Open-label minocycline treatment at 1.4 mg/kg/day

Minocycline

Sex: Female, Male

Region of Enrollment

The Mann-Whitney U-test was used to compare pre-/post-treatment differences in analyte concentrations in serum, plasma and CSF. The Mann-Whitney U test generates a z-score test statistic with an associated p value. A negative z-statistic reflects a decrease in analyte level from pre- to post-treatment. Statistical significance level was set at 0.05. There is one test statistic (z-score) per analyte, reflecting the pre-post comparison across all subjects.
Pre and post treatment measurements of csf analytes: TNF alpha, Il-6, CCL-2(MCP-1), CCL3 (MIP-1alpha), CCL5(RANTES), CXCL(IL-8), BDNF, CD40L, GDNF, HGF, Leptin

z Score

This instrument has two scales - Severity (CGI-S). The CGI-S is a seven point scale with a minimum score of 1 and a maximum score as 7 as follows: 1 = normal, not at all ill; 2 = borderline ill; 3 = mildly ill; 4 = moderately ill; 5 = markedly ill; 6 = severely ill; and 7 = among the most extremely ill patients.

Clinical Global Impressions Scale-Severity (CGI). (Connors & Barkley, 1985)

Overall Study

Dr. Susan Swedo

Overall Study/Minocycline

Autism

Regressive Autism

Childrens National Medical Center

National Institutes of Health Clinical Center, 9000 Rockville Pike

Minocycline to Treat Childhood Regressive Autism

Treatment of Childhood Regressive Autism With Minocycline: an Anti-Inflammatory Agent Active Within the CNS

National Institute of Mental Health (NIMH)

amyotrophic lateral sclerosis

vomă

vomiting

amyotrophic lateral sclerosis/vomă

Minocycline to Treat Childhood Regressive Autism

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