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anorexia/epuizare

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Factors mutated in the D1 cap region

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TECHNICAL FIELD The present invention relates to a novel mutant of a human ciliary neurotrophic factor (hereinbelow abbreviated as human CNTF) and a protein having a four-helix bundle structure similar to that of human CNTF, which are expected to be useful for the treatment of neuropathic diseases.

Serotonin and norepinephrine reuptake inhibitors and uses thereof

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BACKGROUND OF THE INVENTION The market for neuroscience and women's health drugs has been moving towards the use of dual serotonin and norepinephrine reuptake inhibitors (SNRI) for first line treatment of various indications, as evidenced by the recent development of SNRI's such as Venlafaxine and

Serotonin and norepinephrine reuptake inhibitor and uses thereof

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Log In / Înregistrare
BACKGROUND OF THE INVENTION The market for neuroscience and women's health drugs has been moving towards the use of dual serotonin and norepinephrine reuptake inhibitors (SNRI) for first line treatment of various indications, as evidenced by the recent development of SNRI's such as Venlafaxine and

Method for the management of cancer and cancer treatment-related comorbidities

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TECHNICAL FIELD The invention concerns a method for the management of cancer and treatment cancer comorbidities, including but not limited to cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, impaired cognitive function, loss of appetite, muscle weakness, nausea,

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

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BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

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BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the

2-halo-5-alkynyl-pyridyl nicotinic ligands

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BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels in the central nervous system (CNS) and the peripheral nervous system (PNS). The nAChRs serve a wide range of physiological functions, and have been implicated in a number of pathological

2-halo-5-alkynyl-pyridyl nicotinic ligands

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Log In / Înregistrare
BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels in the central nervous system (CNS) and the peripheral nervous system (PNS). The nAChRs serve a wide range of physiological functions, and have been implicated in a number of pathological

Phenyl-substituted nicotinic ligands, and methods of use thereof

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BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the

Phenyl-substituted nicotinic ligands, and methods of use thereof

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BACKGROUND OF THE INVENTION Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the

Ligands for nicotinic acetylcholine receptors, and methods of making and using them

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BACKGROUND OF THE INVENTION The endogenous cholinergic neurotransmitter, acetylcholine, exert its biological effect via two types of cholinergic receptors; the muscarinic ACh receptors and the nicotinic ACh receptors. As it is well established that muscarinic ACh receptors dominate quantitatively

Cytokine antagonists for neurological and neuropsychiatric disorders

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FIELD OF THE INVENTION The present invention relates to novel methods of use of specific cytokine antagonists for the treatment of neuropsychiatric and neurological disorders in humans. More particularly, these cytokine antagonists are used in a new treatment of neuropsychiatric and neurologic

Cytokine antagonists for neurological and neuropsychiatric disorders

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FIELD OF THE INVENTION The present invention relates to novel methods of use of specific cytokine antagonists for the treatment of neuropsychiatric and neurological disorders in humans. More particularly, these cytokine antagonists are used in a new treatment of neuropsychiatric and neurologic
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