antipsychotics/infarction

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Antipsychotic use and myocardial infarction in older patients with treated dementia.

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BACKGROUND Antipsychotic agents (APs) are commonly prescribed to older patients with dementia. Antipsychotic use is associated with an increased risk of ischemic stroke in this population. Our study aimed to investigate the association of AP use with the risk of acute myocardial infarction

Effect of the antipsychotic drug haloperidol on arrhythmias during acute myocardial infarction in a porcine model.

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Patients receiving psychiatric medication, like the antipsychotic drug haloperidol, are at an increased risk of sudden cardiac death (SCD). Haloperidol blocks the cardiac rapidly-activating delayed rectifier potassium current, thereby increasing electrical dispersion of repolarization which can

Acute myocardial infarction improved by neuroleptic analgesic therapy.

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Treated with orthodox therapy, a 58-year-old man with acute myocardial infarction of the anteroseptal and lateral walls continued having lethal arrhythmias, reinfarction, low blood pressure, and anuria. With modified neuroleptic analgesic therapy, which consisted only of a continuous drip injection

The association between antipsychotic agents and the risk of myocardial infarction: a systematic review.

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OBJECTIVE Patient populations that are prescribed antipsychotic agents have higher cardiovascular mortality rates. The risk of myocardial infarction is influenced by various factors that are more prevalent in patients with a mental illness. The aim of this review was to determine whether the use of

Myocardial infarction: an unusual complication of neuroleptic malignant syndrome.

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A case of myocardial infarction in the absence of risk factors, concurrent with neuroleptic malignant syndrome, is presented, suggesting the existence of a causal relation between the two. Possible pathophysiological mechanisms will be discussed.

Cerebral infarction in neuroleptic malignant syndrome.

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Two young women with no risk factors for cerebrovascular disease developed hyperpyrexia, rigidity, and autonomic features while taking neuroleptic agents. The first presented with increasing rigidity, profuse diaphoresis and dehydration, and a right hemiparesis, and computed tomography (CT) showed a

Multiple cerebral infarction associated with neuroleptic-induced lupus anticoagulant.

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A 39 year old schizophrenic woman with a 20 year history of neuroleptic treatment suffered bilateral cerebral infarcts and coagulation studies revealed a lupus anticoagulant (LA). She highlights the poorly recognized risk of thrombosis in patients on neuroleptics who develop LA. In this case the LA

Neuroleptic malignant syndrome and acute myocardial infarction: case report and review.

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The neuroleptic malignant syndrome (NMS) is a potentially life threatening reaction usually observed following administration of dopaminergic antagonists (neuroleptic medications, e.g., phenothiazines, thioxanthenes, and haloperidol). NMS is characterized by mental status changes, muscle rigidity

Antipsychotic exposure prior to acute myocardial infarction in patients with serious mental illness.

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OBJECTIVE To investigate the association between acute myocardial infarction (AMI) and recent exposure to antipsychotic agents in people with serious mental illness (SMI), and modifying influences. METHODS A case-crossover design was applied using the Taiwan National Health Insurance Research

Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.

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To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction. Cohort study using a healthcare database. Nationwide sample of patient data from more than 700 hospitals across the United

Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis.

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There is emerging concern that antipsychotics may be associated with an increased risk of myocardial infarction (MI). A previous review identified five observational studies that did not provide an accurate estimate of the association between antipsychotic drug use and MI risk. More recent studies

Antiarrhythmic properties of a neuroleptic butyrophenone, melperone, in acute myocardial infarction. A double-blind trial.

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In vitro animal studies suggest melperone, a neuroleptic butyrophenone, to be a type III antiarrhythmic drug according to the classification of Vaughan Williams. It has no negative inotropic effect on cardiac muscle. A double-blind trial of 3 hours' duration was carried out with melperone and

Antipsychotics and risk of first-time hospitalization for myocardial infarction: a population-based case-control study.

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BACKGROUND Use of antipsychotics has been linked with an adverse cardiovascular risk factor profile and an increased risk of dysrhythmia and sudden cardiac death. However, detailed data on the association between use of antipsychotics and development of atherosclerotic disease are

[Malignant neuroleptic syndrome associated with myocardial infarction, acute renal insufficiency and rhabdomyolysis].

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We present a case of malignant neuroleptic syndrome in a 55 years old male diagnosed 3 years ago of alcoholic paranoid psychosis who was chronically treated with haloperidol, clothiapine, and phenobarbital. Twenty one days after neuroleptic drug withdrawal the patient was admitted to the recovery

[A case of multiple pulmonary infarctions associated with Sjögren's syndrome and antipsychotic agent administration].

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A 56-year-old woman presented with complaints of general malaise and left chest pain. Chest radiography and CT scanning revealed multiple nodules and infiltrations in both lung fields. Her symptoms diminished and the extent of some of the lung shadows decreased spontaneously. However, since new

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