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Use of antipsychotic medication in chemotherapy-induced nausea and vomiting.

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Nausea and vomiting continue to present significant problems for cancer patients undergoing chemotherapy. Initial work suggested an important role for central dopamine transmission in the underlying pathophysiology. However, recent evidence has implicated central and peripheral serotonin release.

Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds.

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Small rodents (mice, rats) are the species of choice for evaluating the pharmacology of centrally acting compounds, such as antipsychotics, whereas toxicology data are routinely obtained from other species (rabbits, dogs, monkeys). Whilst there is a substantial number of "therapeutically relevant"

Feasibility of olanzapine, multi acting receptor targeted antipsychotic agent, for the prevention of emesis caused by continuous cisplatin- or ifosfamide-based chemotherapy.

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Background To determine the feasibility and efficacy of olanzapine, which is approved by the Pharmaceuticals and Medical Devices Agency as multi acting receptor targeted antipsychotic agent of the thienobenzodiazepine class, for prevention of chemotherapy-induced nausea and vomiting (CINV) in

[Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients : a review].

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BACKGROUND Many recommendations concerning the treatment of nausea and vomiting in palliative care patients exist but what is the evidence for this? Most studies dealing with this topic have focused on cancer patients under chemotherapy and/or radiation therapy or on patients with postoperative

Chronic Atypical Antipsychotic Use Is Associated With Reduced Need for Postoperative Nausea and Vomiting Rescue in the Postanesthesia Care Unit: A Propensity-Matched Retrospective Observational Study.

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Atypical antipsychotics are efficacious for chemoprophylaxis against chemotherapy-induced nausea and vomiting, but perioperative investigations have been scant. We sought to examine the association between chronic atypical antipsychotic therapy and the likelihood of postoperative

Persistent supersensitivity vomiting following neuroleptic withdrawal in an adolescent.

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Vomiting during neuroleptic withdrawal in children.

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Increased vomiting among patients treated with neuroleptics.

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Neuroleptic-induced emesis: a new indication for clozapine?

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[Comprehensive treatment of vomiting in pregnant women using neuroleptics and parenteral feeding].

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A case report of vomiting related to the interactions of antipsychotics and benztropine.

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[On the use of a neuroleptic in experimental phase in the nausea and vomiting of the pregnant woman].

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Olanzapine for chemotherapy-induced nausea and vomiting: a systematic review.

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OBJECTIVE Newer drugs incorporated in prophylactic regimens for chemotherapy-induced nausea and vomiting (CINV) have resulted in significantly reduced rates of this feared complication of cytotoxic chemotherapy. However, both delayed chemotherapy-induced nausea and breakthrough CINV remain difficult

Responses to apomorphine, amphetamine, and neuroleptics in schizophrenic subjects.

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Twenty-one schizophrenic subjects, who had been neuroleptic-free, were tested for responsiveness to dopaminergic agonists: Apomorphine emesis threshold was determined and change in psychopathology after 0.5 mg/kg d-amphetamine orally was rated. The subjects' subsequent response to neuroleptic

[Changes in positive and negative symptoms, general psychopathology in schizophrenic patients during augmentation of antipsychotics with glycine: a preliminary 10-week open-label study].

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The Glutamatergic system is the most important excitatory system of the human brain. Dysfunction of this system plays an important role in the pathogenesis of numerous psychiatric disorders, including schizophrenia. According to the glutamatergic hypothesis of schizophrenia augmentation of the

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