aspartic acid/hypoxia

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[Glutamic and aspartic acid in complex treatment of circulatory hypoxia].

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[Effect of potassium and magnesium salts of 1-aspartic acid on blood ammonia levels, oxygen consumption and tolerance time in hypoxia].

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[Modulation of hippocampal synaptic transmission in a mouse model of chronic intermittent hypoxia: implications for neurocognitive impairments].

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OBJECTIVE To investigate the effects of chronic intermittent hypoxia (CIH) on neuronal excitatory synaptic transmission in mice and explore their role in CIH-induced neurocognitive impairments. METHODS Three-week old ICR male mice were randomly divided into three experimental groups, the unhandled

Long-lasting effects of chemical hypoxia on spinal cord function in tadpoles.

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We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the

Protective effects of kamikihi-to, a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia in mice and gerbils.

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The protective effects of Kamikihi-To (KMK), a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia were investigated with various experimental models in mice and gerbils. KMK (2.0 g/kg/day, p.o. for 5 days) significantly prolonged the survival time of mice subjected to

The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.

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Hypoxia of the brain may alter further seizure susceptibility in a different way. In this study, we tried to answer the question how episode of convulsion induced by hypoxia (HS) changes further seizure susceptibility, and how N-methyl-D-aspartic acid (NMDA) and AMPA/KA receptor antagonists

Aspartic acid administered neonatally affects ventilation of male and female rats differently.

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In this study ventilation was evaluated in 12-mo-old male and female rats who had received large doses of aspartic acid neonatally. Rats of both sexes treated with aspartic acid were obese, stunted, and exhibited hypogonadism. Although metabolic rates of the aspartic acid-treated rats were not

Molecular cloning and characterization of a hypoxia-responsive CITED3 cDNA from grass carp.

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We have isolated a 1586-bp full-length CITED3 cDNA from grass carp which specifies for a cAMP-responsive element-binding protein/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich C-terminal domain protein. The cDNA, designated as gcCITED3, has an open reading frame of 762

Multifunctional Micelles Dually Responsive to Hypoxia and Singlet Oxygen: Enhanced Photodynamic Therapy via Interactively Triggered Photosensitizer Delivery.

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Nanoparticulate antitumor photodynamic therapy (PDT) has been suffering from the limited dose accumulation in tumor. Herein, we report dually hypoxia- and singlet oxygen-responsive polymeric micelles to efficiently utilize the photosensitizer deposited in the disease site and hence facilely improve

Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells.

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Ultraviolet A (UVA) irradiation is responsible for a variety of changes in cell biology. The purpose of this study was to investigate effects of aspartic acid on UVA irradiation-induced damages in the stemness properties of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Furthermore,

Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.

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The acute effects of hypoxia and/or hypoglycaemia on DC potentials recorded from CA1 pyramidal neurones of the gerbil hippocampal slice maintained in vitro were investigated. Depolarizing potential changes were recorded when the slice was superfused with the excitatory amino acid agonists: NMDA

Acute effects of aspartic acid on ventilation of male and female rats.

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The effects of aspartic acid (aa) on ventilation were evaluated in awake male and female rats prior to and 15, 30, and 45 minutes after saline, 100 mg/kg or 580 mg/kg aa was injected subcutaneously. Subsequently, rats were exposed to hypoxic and hypercapnic gas challenges. In males, 100 mg/kg aa

Involvement of excitatory neurotransmitters in the damage produced in chick embryo retinas by anoxia and extracellular high potassium.

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Chick embryo retinas were exposed for 40 min to anoxic conditions and the resulting histological changes were studied by light microscopy. A strong edematous response with severe swelling of the inner nuclear, inner plexiform and ganglion cell layers and numerous cells with pyknotic nuclei but very

Brain amino acids in conscious rats in chronic normocapnic and hypocapnic hypoxemia.

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The influence of hypoxemia on the brain content of several organic acids and NH+4, AND ITS RELATIONship to the accompanying hypocapnia was studied in unanesthetized rats subjected to hypoxemia for periods ranging between 2 hours and 7 days. Under acute conditions, 'mild' hypoxemia (FO2 = 6--7%),

Effect of adenosine A1 and A2 receptor stimulation on hypoxia-induced convulsions in adult mice.

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Clinical observations indicate that seizures induced by hypoxia are common kind of convulsive activity in both infants and elderly patients. The occurrence of seizure episode during hypoxia is important risk factor of epilepsy development in the future. Experimental hypoxia was obtained by exposure

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