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Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells.

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A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of

Design and construction of resonant cavity applicator for brain tumor hyperthermia treatment without contact.

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A re-entrant type resonant cavity applicator for brain tumor hyperthermia treatment is presented. In this method, a human brain is placed between the gap of the inner re-entrant cylinders without contact. This cavity has a window for insertion of the human head. Here, first, to design and construct

Volumetric interstitial hyperthermia: nursing implications for brain tumor treatment.

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Malignant glioma is a devastating disease which presents a clinical challenge to physicians and neuroscience nurses. It carries a dismal prognosis, with a median survival of only nine months following application of conventional therapies of surgical resection, radiotherapy and chemotherapy.

[Interstitial hyperthermia of malignant brain tumors using implant heating system (IHS)].

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We have developed an implant heating system (IHS) for interstitial hyperthermia of brain tumors. IHS consists of three compartments: ferromagnetic implant with low Curie point, induction coil and generator to produce high frequency magnetic field. The device works as follows: It is heated up to a

Stereotactic hyperthermia for brain tumors.

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We have developed a localized hyperthermia system using computed tomography-stereotactic surgery as malignant brain tumor therapy. In an experimental study, the temperature in the area of the cat brain within 20 mm from a radiofrequency electrode reached more than 43.7 degrees C. Intravenous

[Radiofrequency hyperthermia in malignant brain tumors: clinical trials].

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Local hyperthermia using 13.56-MHz radiofrequency (RF) capacitive heating was evaluated in 19 patients with malignant brain tumor. Intraoperative heating was performed in 4 patients. RF applicators were placed on the cerebral convexity and medial surface with the tumor between them. RF power was

Paroxysmal autonomic dysregulation with fever that was controlled by propranolol in a brain neoplasm patient.

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Intractable fever in cancer patients is problematic and the causes of this fever can be diverse. Paroxysmal persistent hyperthermia after sudden mental change or neurologic deficit can develop via autonomic dysregulation without infection or any other causes of fever. Paroxysmal hyperthermic

Development of the re-entrant type resonant cavity applicator for brain tumor hyperthermia - experimental heating results.

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A re-entrant type resonant cavity applicator for brain tumor hyperthermia treatment is presented. In this method, a human head is placed between the gap of the inner re-entrant cylinders, and is heated with electromagnetic fields stimulated in the cavity without contact between the surface of the

SAR analysis of a re-entrant resonant cavity applicator for brain tumor hyperthermia treatment with a 3-D anatomical human head model.

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A re-entrant resonant cavity applicator system for non-invasive brain tumor hyperthermia treatments was presented. We have already confirmed the effectiveness of the heating properties of this heating system with cylindrical agar phantoms and with computer simulations.

Effect of combined treatment with magnetic induction hyperthermia and chemotherapy in a rabbit brain tumor model.

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The effects of interstitial magnetic induction hyperthermia alone and in combination with chemotherapy were evaluated in a rabbit brain tumor model. VX2 carcinoma cells were implanted intracerebrally in 28 rabbits. The animals were divided into four groups of seven each, and the experimental

Hyperthermia for brain tumors: improved delivery with a new cooling system.

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Hyperthermia has emerged as an adjunct to other forms of brain tumor therapy. Interstitial microwave irradiation is an effective method of inducing localized brain hyperthermia. One of the problems with this technique, however, is the overheating of tissue adjacent to the antenna. In this study, a

Radiofrequency hyperthermia for malignant brain tumors: preliminary results of clinical trials.

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Local hyperthermia by 13.56-MHz radiofrequency (RF) capacitive heating was evaluated in 16 patients with malignant brain tumors. Intracranial heating during operation was performed in 4 patients. RF applicators with a cooling system were placed on the cerebral convexity and medial brain surface with

Interstitial hyperthermia of malignant brain tumors by an implant heating system using stereotactic techniques.

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Interstitial hyperthermia of malignant brain tumors has been produced by a heated ferromagnetic implant with a low Curie point. Induction heating of the implant, which is stereotactically implanted in a tumor, is obtained by eddy currents in a high-frequency magnetic field. Safe, repeated and

Feasibility of ultrasound hyperthermia in the treatment of malignant brain tumors.

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In order to test the biological feasibility of using ultrasound-generated hyperthermia for the treatment of brain tumors, damage threshold studied and thermal dosimetry studies as a function of temperature were performed in 44 acute experiments in cats. Bilateral craniotomies were performed to

Treatable domain and optimal frequency for brain tumors during ultrasound hyperthermia.

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OBJECTIVE To examine the optimal ultrasound frequency and the treatable domain determined by the tumor size and tumor depth when an external ultrasound heating system is employed for the brain tumor hyperthermia. METHODS This work employs a simplified model of a scanned ultrasound transducer power

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