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Hepatotoxicity of butylated hydroxytoluene and its analogs in mice depleted of hepatic glutathione.

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Butylated hydroxytoluene (2,6-di-tert-butyl-4-methylphenol, BHT) has been reported to be a lung toxicant. Mice treated with BHT (200-800 mg/kg, po) in combination with an inhibitor of glutathione (GSH) synthesis, buthionine sulfoximine (BOS; 1 hr before and 2 hr after BHT, 4 mmol/kg per dose, ip)

Glutathione Counteracts the Effects of Japanese Cedar (Cryptomeria japonica) Pollen Allergen Cry j1

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Japanese cedar (Cryptomeria japonica) pollen allergen Cry j1 increases the intracellular calcium concentration in human keratinocytes, and also impairs the epidermal barrier function. Here, we show that reduced glutathione (GSH) blocks both thrombin activation and the Cry j1-induced intracellular

Hydroethanolic extract of the inner stem bark of Cedrela odorata has low toxicity and reduces hyperglycemia induced by an overload of sucrose and glucose.

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BACKGROUND Cedrela odorata L. (Meliaceae) is a native plant of the Amazon region and its inner stem bark is used in the treatment of diabetes in the form of maceration in Brazilian popular medicine. Until now, there is no scientific study on this activity. The present study was aimed at evaluating

Stimulation of activity and expression of antioxidant enzymes by solvent fractions and isolated compound from Cedrela sinensis leaves in HepG2 cells.

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Cedrela sinensis has been widely used in traditional Oriental medicine to treat a variety of diseases. However, little is known about the cellular actions by which this plant mediates its antioxidant effects. In this study, activity-guided fractionations of C. sinensis leaves were performed using

[Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study].

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Allergic response is induced by the Th2-type immune response. The intracellular thiol redox status of antigen-presenting cells (APCs) reportedly regulates the Th 1/Th 2 balance via distinctive cytokine production by APCs. The beta-1,3-glucan, lentinan, induces reductive macrophages (RMp) with

Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family.

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BACKGROUND Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal pollinosis, and more than 10% of Japanese people suffer from this allergic disorder. However, only two major pollen allergens, Cry j 1 and Cry j 2, have been identified and exclusively characterized. OBJECTIVE The

Effects of a Saccharomyces cerevisiae fermentation product in receiving diets of newly weaned beef steers I: Growth performance and antioxidant defense.

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To evaluate the effects of a Saccharomyces cerevisiae fermentation product (SCFP; Original XPC, Diamond V, Cedar Rapids, IA) on growth performance and antioxidant defense of newly weaned beef cattle, 180 single-source steers (278 ± 21 kg; SD) were used in a 56-d receiving study. Seven days after

Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.

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Quercitrin is found in many kinds of vegetables and fruits, and possesses various bioactive properties. The aim of the present study was to elucidate hepatoprotective mechanisms of quercitrin isolated from Toona sinensis (Juss.) M.Roem. (syn. Cedrela sinensis Juss.), using acetaminophen

Effect of source and concentration of selenium on growth performance and selenium retention in broiler chickens.

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A 6-wk experiment was conducted using 360 one-day-old Jumbo Cornish Cross broiler chicks to evaluate the effects of the source and concentration of Se on growth performance and Se retention. Broilers were fed corn-soy-based diets formulated to contain 0 (negative control), 0.1, 0.2, or 0.3 ppm of

Evaluation of softwood and hardwood sawmill wastes impact on the common carp "Cyprinus carpio" and its aquatic environment: An oxidative stress study.

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The aquatic pollution due to sawmill wood wastes constitutes a major threat to hydro-chemical and fauna characteristics of the aquatic ecosystems. When this kind of organics wastes enter aquatic environment it can be taken up by aquatic organisms through respiration and/or through their diet. This

Plant self-defense mechanisms against oxidative injury and protection of the forest by planting trees of triploids and tetraploids.

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The depletion of the ozone layer, and the resulting substantial increase in incident ultraviolet (UV) irradiation and subsequent oxygen radical formation on the Earth, have caused an extensive variety of damage to the world's forests. Superoxide dismutase (SOD), catalase, and glutathione peroxidase

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