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cepharanthine/atrofiere
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Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus.
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The effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus were examined electron microscopically. Both cepharanthine and minoxidil stimulated cell proliferation and delayed initiation of differentiation and
Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells.
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Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha that has a variety of biological activities in multiple diseases. Spinal and bulbar muscular atrophy (SBMA) is a late-onset neurodegenerative neuromuscular disease without effective therapy, and the protein toxicity of
Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.
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Biscoclaurine-type alkaloids were examined for ability to act as membrane-stabilizing agents and to protect against lipid peroxidation and deterioration of biological membrane. The following results were obtained. Biscoclaurine-type alkaloids inhibit Fe2+-induced lipid peroxidation of biological
Improvement of the anoxia-induced mitochondrial dysfunction by membrane modulation.
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The mitochondrial dysfunction induced by anoxia in vitro was improved with chlorpromazine, cepharanthine, bromophenacyl bromide, and mepacrine without affecting phospholipid or adenine nucleotide metabolisms. The drugs inhibited lipid peroxidation by Fe2+, mitochondrial disruption by Ca2+, and
Changes in mitochondrial function by lipid peroxidation and their inhibition by biscoclaurin alkaloid.
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During in vitro investigation of changes in mitochondrial function accompanying lipid peroxidation, it was found that cepharanthine, a biscoclaurin alkaloid, protects against such change. Results obtained were as follows: (1) Fe2+ induces lipid peroxidation of isolated mitochondria, resulting in
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