delirium/accident vascular cerebral

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Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults

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The Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) describes delirium as a "disturbance in attention (i.e., reduced ability to direct, focus, sustain, and shift attention) and awareness (reduced orientation to the environment)". In addition, a "disturbance in cognition (e.g.,

Cerebral Small Vessel Disease and Perioperative Covert Stroke

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With the growing number of the older population, surgery for elderly patients is on the rise. Elderly patients often have more cardiovascular disease and brain vulnerability and tend to experience more perioperative complications. Perioperative covert stroke is one of those that can been neglected

Direct and Indirect Impact of COVID-19 In Older Populations

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In December 2019, Wuhan city in China, became the center of an outbreak of pneumonia due to a novel coronavirus SARS-CoV-2, which disease was named coronavirus disease 2019 (COVID19) in February, 2020, by WHO. The COVID19 is much more dangerous for people over 60 with a death rate of 3.6% after 60,

Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery

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Postoperative neurocognitive impairments often occur in elderly patients undergoing major surgery, including postoperative delirium(POD) characterized by an acute change in cognition with altered consciousness and impaired attention, and postoperative cognitive dysfunction(POCD) mainly manifested as

Renin as a Biomarker of Haemodynamic Normalisation

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The renin-angiotensin aldosterone system (RAAS) is integral to cardiovascular homeostasis and involved in the regulation of blood pressure, electrolyte balance and intravascular volume. Renin is produced from the renal juxtaglomerular cells and converts angiotensinogen to angiotensin. Angiotensin is

Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients

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Delirium and cognitive decline are common following cardiac surgery and increase the burden on patients and health care resources. Covert (sub-clinical) strokes are associated with these complications. The investigators conducted a prospective cohort pilot study enrolling consecutive cardiac surgery

Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery

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Surgical resection is the main treatment for patients with non-small cell lung cancer (NSCLC) and continuous efforts have been made to evolve surgical strategies and techniques. It has been now been realized that perioperative period is characterized with profound changes and anesthesia management

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation

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Liver Transplant Liver transplantation (LT) is a life-saving procedure for patients with end-stage liver disease. Despite continuous advancement in technology, it remains a high-risk operation. The building-up of an oxygen debt during LT can lead to an increased risk of poor postoperative outcomes

Discovery for Biomarkers and Risk Factors for Postoperative Delirium in Elderly Patients With Spine Surgery

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Method: 1. Study design: This study is a prospective investigation that identifies risk factors for postoperative delirium and searches for predictive biomarkers of delirium. 2. Inclusion criteria / Exclusion Criteria 1. Inclusion criteria - Elderly patients over 70 - Eligible Surgeries: lumbar

Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery

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This clinical trial is performed at Puerta de Hierro Hospital in Spain. The protocol has been approved by institutional ethical committee and Spanish Agency of medicines and medical devices (AEMPS). The aim of the study is to evaluate superiority of Del Nido cardioplegia solution compared to cold

TMS and Exposure Therapy

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OVERVIEW The experiment will consist of four days. Day 1 will include informed consent, questionnaires, a behavioral approach test with a spider, a series of short exposures with a spider, and the first TMS treatment (for a total of approximately 75-90 minutes). Day 2 will occur one to two days

Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System

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1. Title of the Research Project： Study of Regional cerebral Oxygenation and Brain Blood Volume change during Carotid Endarterectomy using the NeurOS system (COBBV-CE Trial) 2. Background/Problem Statement: The use of regional cerebral oxygenation (rSO2) monitoring has grown clinically, even

Melatonin for Prevention of Post Stroke Delirium

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Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System

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1. Title of the Research Project： Study of regional Cerebral Oxygenation and Brain Blood Volume changes during Cardiac Surgery using the NeurOS system (COBBV-CS Trial) 2. Background/Problem Statement: The use of regional cerebral oxygenation (rSO2) monitoring has grown clinically, even becoming the

Assessment of Immediate Postoperative Delirium (IPD) in Adult Patients: Incidence and Etiologic Factors

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Decision to perform this observational study was made due to the lack of information on the local incidence and risk factors for the development of immediate postoperative delirium (IPD). A literature review was done to study the already implicated perioperative causative factors as well as other

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