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Single Shot Lumbar Erector Spinae Plane (ESP) Block in Total Hip Replacement (THR)

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After a pilot study regarding opioid use for patient after THR, the sample size for either treatment or control arm is calculated to be 35 patients per group to achieve adequate power to detect such a difference. Sealed opaque envelopes with allocation inside is prepared forehand and is subsequently

Muscle Dysfunction in Critical Illness

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Patients surviving critical illness experience significant skeletal muscle dysfunction and weakness. Muscle atrophy suffered during critical illness has a long-term impact on the functionality and mobility of these individuals.1-6 The underlying etiology is multifactorial, but largely thought to be

Effect of Dexmedetomidine on Postoperative Delirium Inflammasome Activation Inhibition

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Delirium is an acute and subacute comorbid syndrome characterized by decreased awareness and cognitive dysfunction accompanied by attention deficit. It varies from 20% to 80% in patients entering the ICU. If delirium occurs in the intensive care unit, complications such as unintended intubation,

Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's

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Long-lasting post-operative cognitive dysfunction (POCD) is now a well-recognised complication of surgery, anaesthesia and critical care. It has been shown that cognitive impairment in critical care survivors can be worse than cohorts diagnosed with Mild Cognitive Impairment and approaching those

Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia

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- In this randomized controlled trial, the investigator will compare the incidence of postoperative delirium after total knee arthroplasty between 3 intraoperative sedation regimens including (1) propofol-fentanyl (2) dexmedetomidine -fentanyl (3) fentanyl alone - Anesthesia techniques include

PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit.

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An increasing number of patients are treated at ICUs worldwide. The majority of these patients survive critical illness and are discharged from hospital. In recent decades, improved therapy and survival at ICUs has increased focus on long term outcomes and post-ICU rehabilitation. Both physical and

Training Intervention in Heart Failure and Frail Elderly Population

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HYPOTHESIS Comprehensive intervention fragility in patients older than 70 years after hospitalization for cardiac decompensation improves survival and quality of life of these patients and reduces decompensation and hospital admissions. OBJECTIVES Main objective: 1. Check if a comprehensive program

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

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50% of patients who undergo esophageal and/or lung resection suffer from acute brain dysfunction or delirium postoperatively. Delirium is a state of brain failure characterized by disturbance of consciousness with reduced ability to focus, sustain, or shift attention that occurs over a short period

Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction

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Background: Anesthesia care for elective surgery of patients that are in their seventies or eighties is an ever-growing entity in clinical practice, given the demographic development in many countries of the Western world. Cognitive decline of variable degree is frequently observed after major

Compression in Anklefracture Treatment, The CAT-study

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Malleolar fractures Surgical treatment of patients with malleolar fractures imposes a special challenge for orthopaedic surgeons. A typical ankle fracture results in haematoma, sometimes blistering and almost always oedema formation. This postpones the optimal time for surgery. When operating on a

Safety of Spinal Anesthesia in Patients With Tibial Shaft Fracture

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For some of the patients RA may be even more safe than GA. According to a large meta-analysis RA reduces the risk of several complications versus GA. - Risk of deep vein thrombosis is reduced by 44% - Risk of pulmonary embolism is reduced by 55 % - Risk of major bleeding is reduced by 50% - Risk of

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