delirium/necroză

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Association of serum brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-alpha (TNF-α) with diagnosis of delirium in oncology inpatients.

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OBJECTIVE To evaluate brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) blood levels as disease biomarkers of delirium in oncology inpatients. METHODS Seventeen oncology inpatients with delirium, 28 oncology inpatients without delirium, and 25 non-oncology controls

[Acral skin necrosis in a patient with malaria].

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A case of acral skin necrosis in a 21-year-old farm workman, associated with Plasmodium falciparum malaria is reported. Patient presented jaundice, disorientation and delirium, high parasitemia, hypoglycemia, anemia, low platelets, and dark necrotic maculae surrounded by an erythematous halo,

Effects of dexmedetomidine on emergence delirium in pediatric cardiac surgery.

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BACKGROUND The present study aimed to investigate the effects of dexmedetomidine on emergence delirium (ED) in pediatric patients undergoing cardiac surgery. METHODS Fifty children of both sexes aged 1-6 years weighing 10-25 kilograms, with American Society of Anesthesiologists (ASA) physical status

Evaluating Mechanisms of Postoperative Delirium and Cognitive Dysfunction Following Elective Spine Surgery in Elderly Patients (CONFESS): Protocol for a Prospective Observational Trial.

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Elderly people are at particular high risk for postoperative delirium (POD) following spine surgery, which is associated with longer hospital stays, higher costs, risk for delayed complications, long-term care dependency, and cognitive dysfunction (POCD). It is insufficiently

Fatal hyperthermia associated with excited delirium during an arrest.

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An autopsy case of fatal hyperthermia in a state of excited delirium is reported. On a hot summer night a 39-year-old man was suspected of being a rapist, and police officers and several men attempted to arrest him. He vigorously resisted, but after a 20-min struggle he was ultimately forced into a

Management of infected pancreatic necrosis in the setting of concomitant rectal cancer: A case report and review of literature.

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Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in

[Delirium is a very common and life-threatening condition].

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Although a lot is known regarding the epidemiology and aetiology of this condition, the pathophysiology of delirium remains poorly understood. Today, the leading hypothesized mechanism for the pathogenesis of delirium focuses on a central cholinergic deficiency and dopamine excess. Besides, other

[Role of α7 nicotinic acetylcholine receptor in attenuation of endotoxin induced delirium with dexmedetomidine in mice].

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OBJECTIVE To observe the role of α7 nicotinic acetylcholine receptor (α7nAChR) in the protection against delirium by the use of dexmedetomidine (DEX) in endotoxin derived delirium and its mechanism. METHODS 100 male adult C57BL/6 mice were randomly divided into normal saline control group (NS

Prognostic value of acute delirium recovery in older adults.

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OBJECTIVE To analyze the prognostic impact of short-term changes in the intensity of delirium in association or not with sepsis. We also aimed to analyze if s100B, a serum protein derived from astrocytes related to cerebral damage, could be a marker of delirium or sepsis. METHODS We included 47

In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task.

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Quetiapine, an atypical antipsychotic medication has lacked pre-clinical validation for its purported benefits in the treatment of delirium. This laboratory investigation examined the effects of quetiapine on the attentional set shifting task (ASST), a measure of cognitive flexibility and executive

Delirium and the functional recovery of older medical inpatients after acute illness: the significance of biological factors.

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Previous studies have not clarified the relationship of delirium to functional capacity during acute illness. We have investigated this relationship, incorporating the potential roles of APOE genotype and circulating cytokines in a longitudinal study of acutely admitted patients aged 70+ years. In

The effect of the timing and dose of dexmedetomidine on postoperative delirium in elderly patients after laparoscopic major non-cardiac surgery: A double blind randomized controlled study.

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OBJECTIVE There were few clinical data dosing and timing regimen for preventing postoperative delirium. The present study aimed to investigate the effect of the timing and dose of dexmedetomidine on postoperative delirium in elderly patients after laparoscopic major non-cardiac surgery. METHODS A

Inflammation biomarkers and delirium in critically ill patients.

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BACKGROUND Delirium is a common occurrence in critically ill patients and is associated with an increase in morbidity and mortality. Septic patients with delirium may differ from a general critically ill population. The aim of this investigation was to study the relationship between systemic

Associations of markers of inflammation and coagulation with delirium during critical illness.

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OBJECTIVE To assess the associations between a priori-selected markers of inflammation and coagulation and delirium during critical illness. METHODS In this prospective cohort study, we collected blood from mechanically ventilated medical intensive care unit (ICU) patients and measured nine plasma

Delirium in patients with acute ischemic stroke admitted to the non-intensive stroke unit: Incidence and association between clinical features and inflammatory markers.

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BACKGROUND Stroke patients with development of delirium have unfavorable outcomes, higher mortality, longer hospitalizations, and a greater degree of dependence after discharge. Studies suggest that delirium is associated with abnormal immunological responses and a resultant increase in inflammatory

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