diazepam/neoplasms

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Diazepam during endoscopic submucosal dissection of gastric epithelial neoplasias.

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OBJECTIVE To investigate risk factors and adverse events related to high-dose diazepam administration during endoscopic submucosal dissection for gastric neoplasias. METHODS Between February 2002 and December 2009, a total of 286 patients with gastric epithelial neoplasia underwent endoscopic

Increased expression of diazepam binding inhibitor in human brain tumors.

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Benzodiazepines, which are in extensive clinical use, can regulate neoplastic growth via benzodiazepine receptors. We have studied the expression of the diazepam binding inhibitor (DBI) polypeptide, a putative endogenous ligand for benzodiazepine receptors in normal and pathological human brain. In

Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.

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This study examined the comparative anticancer effects of flavonoids and diazepam in the cultured cancer cells. In the SNU-C4 colorectal and MDA-MB-231 breast adenocarcinoma cells, apigenin and fisetin, flavonoids, and diazepam inhibited cancer cell survival concentration and incubation-time

Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.

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Benzodiazepines (BZD) have been described to interact with specific peripheral-type receptors on phagocytes. The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1

Mutagenic activity of diazepam evaluated by in vivo cytogenetic tests.

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BACKGROUND Diazepam, one of the benzodiazepine group of tranquilizers, is used as an adjunctive drug for sedation and for relief of anxiety in the treatment of epilepsy. Suspicion has been aroused of a possible mutagenic and teratogenic effect of this drug, thus the potential for cancer

A research study review of effectiveness of treatments for psychiatric conditions common to end-stage cancer patients: needs assessment for future research and an impassioned plea.

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Rates of psychiatric conditions common to end-stage cancer patients (delirium, depression, anxiety disorders) remain unchanged. However, patient numbers have increased as the population has aged; indeed, cancer is a chief cause of mortality and morbidity in older populations. Effectiveness of

Nonestrogenic drugs and breast cancer.

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The relation between breast cancer and selected nonestrogenic drugs was evaluated in the Group Health Cooperative of Puget Sound, Seattle, Washington, a prepaid health care organization with computerized information on diagnoses and outpatient drug use. No important positive associations with breast

[Influence of propofol and isoflurane on cytokines response to cancer surgery during perioperative period].

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OBJECTIVE To compare the influence of propofol and isoflurane on pro-inflammatory and anti-inflammatory cytokine response to perioperative period of tongue cancer surgery. METHODS Twenty-four adult patients undergone the operation of tongue cancer were assigned to two groups randomly, propofol group

Ketamine as an adjuvant to opioids for cancer pain.

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BACKGROUND Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective. Ketamine is known to have hallucinogenic side effects. To date no systematic review

Ketamine as an adjuvant to opioids for cancer pain.

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BACKGROUND This is an update of the original review published in Issue 1, 2003. Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective. Ketamine is

Treatment of acute, severe epigastric/chest pain in a patient with stomach cancer following gastrectomy: A case report.

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The treatment of acute chest pain can be a challenge in palliative care. Firstly, because acute chest pain is a symptom of a paucity of diseases, which makes diagnosis difficult and time consuming, while there is also a time constraint, due to the extreme suffering of the patient. Secondly, the

Coffee-drinking and personality as factors in the genesis of cancer and coronary heart disease.

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A study of the prediction of cancer and coronary heart disease on the basis of coffee consumption and personality shows that in cancer-prone probands (diagnosed on the basis of a personality inventory) coffee consumption was related to low incidence of cancer and high incidence of coronary heart

[Balanced regional anesthesia based on epidural blockade in a patient with gastric tumor and open-form fibrous-cavernous pulmonary tuberculosis].

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Combination of fibrocavernous pulmonary tuberculosis and malignant gastric tumor is very rare. Anesthesia in such patients is associated with a number of difficulties. Balanced regional anesthesia based on epidural blockade and intravenous diazepam and fentanyl is recommended as a method of choice.

Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.

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Glioblastoma multiforme (GBM) is neoplasm which is resistant to all currently used treatment modalities including surgery, radiation therapy and chemotherapy. Photodynamic therapy (PDT) has been suggested as a novel therapeutical approach to the treatment of malignant gliomas. Here, we attempted to

[Extreme duration of action of diazepam as a cause of respiratory insufficiency in a female geriatric patient].

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A 77-year-old woman who had undergone surgery of a non-malignant extracerebral retro-orbital tumor suffered postoperatively from respiratory failure due to impaired respiratory drive and unconsciousness of unknown origin and required artificial ventilation for 14 days. After cerebral and

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