elastase/neoplasms

Linkul este salvat în clipboard

Alegeți tipul de sortare

Pagină 1 din 35 rezultate

Method of assaying leukocyte elastase inhibitor for the in vitro diagnosis of colorectal cancer

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to the cancerology field. More particularly, the subject of the present invention is a method for the in vitro diagnosis of colorectal cancer in a human patient, by determining the presence of the Leukocyte Elastase Inhibitor (LEI) in a biological sample taken from this

Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists

Numai utilizatorii înregistrați pot traduce articole

TECHNICAL FIELD OF THE INVENTION This invention relates to the field of substances which have anti-inflammatory or anti-tumor activity and to diagnostic testing of patients for regulation of tumor necrosis factor and elastase activity. BACKGROUND OF THE INVENTION Tumor necrosis factor (TNF) is an

Beta-hairpin peptidomimetics as selective elastase inhibitors

Numai utilizatorii înregistrați pot traduce articole

The present invention provides .beta.-hairpin peptidomimetics which are useful as inhibitors of protease enzymes and are embraced by the general disclosure of, but not specifically disclosed in WO2006/087001 A1. The .beta.-hairpin peptidomimetics of the invention are compounds of general formula

Beta-hairpin peptidomimetics as selective elastase inhibitors

Numai utilizatorii înregistrați pot traduce articole

The .beta.-hairpin peptidomimetics of the invention are compounds of general formula cyclo(Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.sup- .7-Xaa.sup.8-Xaa.sup.9-Xaa.sup.10-Xaa.sup.11-Xaa.sup.12-Xaa.sup.13-), and pharmaceutically acceptable salts thereof, with Xaa.sup.1,

Enzyme-activated anti-tumor prodrug compounds

Numai utilizatorii înregistrați pot traduce articole

FIELD OF INVENTION The invention relates to prodrug compounds capable of targeting and delivering cytotoxic drugs to tumors and metastatic cells. The drugs are useful in the treatment of cancer. BACKGROUND OF THE INVENTION Although many drugs are known that kill cancer cells, there are apparently

Serine protease inhibitors-N-substituted derivatives

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Method for increasing granulocyte number in a patient by administering superactive IL-33 fragments

Numai utilizatorii înregistrați pot traduce articole

INTRODUCTION Cytokines of the interleukin 1 family (IL-1) play a major role in a large number of autoimmune, infectious and inflammatory diseases (Sims J E and Smith D E, Nature Rev Immunology 2010). Interleukin 33 (IL-33), initially named NF-HEV, is a new cytokine of the IL-1 family comprising 270

Enzyme and DNA sequence encoding krill-derived multifunctional protein

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to purified nucleic acids encoding a krill-derived enzymes such as proteinases, which can be a multifunctional protein, and to purified polypeptides. A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin,

Multifunctional protein and DNA sequence encoding same

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to purified nucleic acids encoding a krill-derived multifunctional protein and to purified polypeptides having multifunctional activity. A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin, collagenase,

Antimicrobial uses of multifunctional enzyme

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to a krill-derived multifunctional enzyme and a family of crustacean and fish derived enzymes having substantial structural similarity to the multifunctional enzyme derived from antarctic krill. The invention additionally relates to the multifunctional enzyme, to

Crustacean and fish derived multifunctional enzyme

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to the discovery that there exists a family of crustacean and fish derived enzymes having substantial structural similarity to an enzyme derived from antarctic krill. The krill enzyme is the subject of U.S. patent application Ser. No. 08/338,501, filed Nov. 22, 1994,

Method for the prevention and treatment of scars with enzymes

Numai utilizatorii înregistrați pot traduce articole

BACKGROUND OF THE INVENTION Collagen is the major structural constituent of mammalian organisms and makes up a large portion of the total protein content of skin and other parts of the animal body. In humans, it is particularly important in the wound healing process and in the process of natural

Serine protease inhibitors-keto and di-keto containing ring systems

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which include elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Val-pro containing .alpha.-keto oxadiazoles as serine protease inhibitors

Numai utilizatorii înregistrați pot traduce articole

BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102 (chymotrypsin numbering system). Human

Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors

Numai utilizatorii înregistrați pot traduce articole

The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in

Anterior
1
2
3
Următor →

Alăturați-vă paginii
noastre de facebook

Herbal & Natural Medicine

Cea mai completă bază de date cu plante medicinale susținută de știință

Funcționează în 55 de limbi
Cure pe bază de plante susținute de știință
Recunoașterea ierburilor după imagine
Harta GPS interactivă - etichetați ierburile în locație (în curând)
Citiți publicațiile științifice legate de căutarea dvs.
Căutați plante medicinale după efectele lor
Organizați-vă interesele și rămâneți la curent cu noutățile de cercetare, studiile clinice și brevetele

Tastați un simptom sau o boală și citiți despre plante care ar putea ajuta, tastați o plantă și vedeți boli și simptome împotriva cărora este folosit.
* Toate informațiile se bazează pe cercetări științifice publicate