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flushing/neoplasms

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Minimization of transport of cancer cells

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to apparatus and methods for use in surgical removal of cancerous tumors. 2. Description of the Prior Art As early as 1885, Gerster reported that surgical treatment for cancer might actually result in

Chromenone analogs as sirtuin modulators

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA repair.

CGRP receptor antagonist

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BACKGROUND OF THE INVENTION The disclosure generally relates to the compound (R)--N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperaz- in-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-- carboxamide (Compound I or the compound of formula I), including

Quinazolinone, quinolone and related analogs as sirtuin modulators

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA repair.

Sirtuin modulating compounds

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

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This application is a 371 of International Application No. PCT/US2012/061015, filed Oct. 19, 2012, which claims the benefit of 61/549,370 filed Oct. 20, 2011. BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Benzimidazoles and related analogs as sirtuin modulators

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to higher eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene
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