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Non-flushing niacin analogues, and methods of use thereof

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BACKGROUND OF THE INVENTION Hyperlipidemia and hypercholesterolemia are conditions that have a well established correlation with increased risk of other conditions, such as heart attacks, atherosclerosis, and other deleterious ailments. There are numerous agents available for lowering cholesterol

Non-flushing niacin analogues, and methods of use thereof

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND OF THE INVENTION Hyperlipidemia and hypercholesterolemia are conditions that have a well established correlation with increased risk of other conditions, such as heart attacks, atherosclerosis, and other deleterious ailments. There are numerous agents available for lowering cholesterol

Non-flushing niacin analogues, and methods of use thereof

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND OF THE INVENTION Hyperlipidemia and hypercholesterolemia are conditions that have a well established correlation with increased risk of other conditions, such as heart attacks, atherosclerosis, and other deleterious ailments. There are numerous agents available for lowering cholesterol

Non-flushing niacin analogues, and methods of use thereof

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND OF THE INVENTION Hyperlipidemia and hypercholesterolemia are conditions that have a well established correlation with increased risk of other conditions, such as heart attacks, atherosclerosis, and other deleterious ailments. There are numerous agents available for lowering cholesterol

Chromenone analogs as sirtuin modulators

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA repair.

Quinazolinone, quinolone and related analogs as sirtuin modulators

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA repair.

Sirtuin modulating compounds

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

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This application is a 371 of International Application No. PCT/US2012/061015, filed Oct. 19, 2012, which claims the benefit of 61/549,370 filed Oct. 20, 2011. BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

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Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Benzimidazoles and related analogs as sirtuin modulators

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BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to higher eukaryotes. The encoded SIR proteins are involved in diverse processes from regulation of gene silencing to DNA

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene

Sirtuin modulating compounds

Numai utilizatorii înregistrați pot traduce articole
Log In / Înregistrare
BACKGROUND The Silent Information Regulator (SIR) family of genes represents a highly conserved group of genes present in the genomes of organisms ranging from archaebacteria to a variety of eukaryotes (Frye, 2000). The encoded SIR proteins are involved in diverse processes from regulation of gene
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