hemoglobinuria/hypoxia

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Perioperative management of patients with paroxysmal nocturnal hemoglobinuria.

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During the past two decades, we have had the opportunity to study a large number of patients with the rare hemolytic anemia, paroxysmal nocturnal hemoglobinuria. Sixteen surgical procedures have been performed upon ten patients with paroxysmal nocturnal hemoglobinuria. From this experience, we have

Markedly high plasma erythropoietin and granulocyte-colony stimulating factor levels in patients with paroxysmal nocturnal hemoglobinuria.

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In patients with paroxysmal nocturnal hemoglobinuria (PNH), we measured plasma concentrations of endogenous hematopoiesis-regulatory cytokines to characterize bone marrow (BM) hypoplasia which is a major cause of death. Contrary to 10 healthy individuals, all 14 patients with PNH showed increases of

Diamphidia toxin, the bushmen's arrow poison: possible mechanism of prey-killing.

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The effects of a 60,000 mol. wt protein from the pupae of the beetle, Diamphidia nigro-ornata have been studied. In concentrations as high as 50 micrograms/ml, the toxin has little effect on the propagated compound action potential of isolated nerve trunks, or on the voltage-gated sodium and

Acetaminophen toxicosis in the cat.

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Administration by the owner of three 325-mg (5-gr) tablets of acetaminophen (N-acetyl-p-aminophenol) to each of 2 adult Burmese cats was associated with severe illness of both cats and death of one. Administration of two 325-mg tablets to each of 2 experimental adult cats resulted in severe illness.

[Pulmonary emboli in sclerotherapy for peripheral vascular malformations under general anesthesia; a report of two cases].

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Sclerotherapy with absolute ethanol and/or polidocanol is a well-established therapeutic modality for the treatment of peripheral vascular malformations, although systemic complications such as hemoglobinuria and pulmonary embolism could occur. We report two cases of pulmonary embolism associated

Hemoglobinemia in rats exposed to high altitude.

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A hemoglobinemia occurred in rats exposed to a simulated altitude of 18,000 ft. No biochemical deficits in the erythrocytes or plasma were apparent, and the erythrocytic survival time was normal. This hypoxia-induced hemoglobinemia was not due to intravascular hemolysis and it coexisted with

Congenital erythrocyte enzyme deficiencies.

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Congenital hemolytic anemias resulting from PK, PFK, and G6PD enzyme deficiencies have been reported in domestic animals. Dogs with PFK deficiency may have episodes of intravascular hemolysis with hemoglobinuria in addition to a persistent compensated hemolytic anemia. Patients with mild G6PD

[Erythropoietin: biochemical characteristics, biologic effects, indications and results of use in hematology].

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This review has two objects: a brief recapitulation of the biological background of erythropoietin (EPO), and a review of its clinical utilization in hematology. EPO, both in its naturally occurring and recombinant form (rH-EPO), is a single chain glycoprotein with an approximate molecular weight of

Polyethylene Oxide (PEO) molecular size determines the severity of atypical thrombotic microangiopathy in a guinea pig model of acute intravenous exposure

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In 2017, Opana ER was voluntarily removed from the US market based on concerns that its risks outweighed its therapeutic benefits. The data that supported this conclusion were based on post- marketing evaluation that demonstrated increased intravenous abuse associated outbreaks of HIV, hepatitis C

Survival after prolonged submersion in freshwater in Florida.

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A 2-year-old boy was submerged for at least 20 min in a freshwater creek in Union County, FL. Cardiopulmonary resuscitation (CPR) was administered for approximately 1 h at the scene and during transport to the hospital. On arrival, his Glasgow coma scale score was 3 and rectal temperature was < or =

Kerosene, Camphor, and Naphthalene Poisoning in Children.

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Kerosene poisoning is one of the most common accidental poisoning in children in developing countries due common use of kerosene in house-hold and unsafe storage practices. Aspiration pneumonitis is the most common manifestation of kerosene ingestion due to its low viscosity, high

A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors.

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BACKGROUND This prospective study was designed to be the first to evaluate the toxicity of radiofrequency ablation (RFA) in patients with recurrent pediatric solid tumors. METHODS From 2003 through 2008, a phase 1/pilot study of RFA for recurrent pediatric solid tumors was conducted. A

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