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hydroxylamine/hemoragie

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ArticoleStudii cliniceBrevete
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Hydroxylamine attenuates the effects of simulated subarachnoid hemorrhage in the rat brain and improves neurological outcome.

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Some of the neurological deficits that emerge after aneurysmal subarachnoid hemorrhage (SAH) in humans are presumably caused by ischemic brain damage consequential to SAH-induced delayed cerebral vasospasm. This vasospasm probably results from an imbalance among vasoactive factors released from both

Studies on the chemical modification of hemorrhagic toxin I from five pace snake (Agkistrodon acutus) venom.

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The chemical modification of hemorrhagic toxin I (AaHI) from Agkistrodon acutus has been studied. Inactivation was observed upon modification of 3 out of 7 histidine residues with diethyl pyrocarbonate. The His residues are deblocked, accompanied by a return of activity, upon treatment with neutral

A high-throughput screening assay of ascorbate in brain samples.

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Ascorbate is a vital reductant/free radical scavenger in the CNS, whose content defines - to a large extent - the redox status and the antioxidant reserves. Quick, reliable and specific methods for its measurement in brain samples are highly desirable. We have developed a new high-throughput

Coronary thrombolysis with facilitated absorption of intramuscularly injected tissue-type plasminogen activator.

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Conventional activators of the fibrinolytic system used for coronary thrombolysis entail unavoidable delay, risk of bleeding, or both in contrast to tissue-type plasminogen activator (t-PA). Because the potential benefit of coronary thrombolysis is inversely related to the duration of antecedent
BACKGROUND Batracylin is a heterocyclic arylamine topoisomerase inhibitor with preclinical anticancer activity. Marked species differences in sensitivity to the toxicity of batracylin were observed and attributed to differential formation of N-acetylbatracylin by N-acetyltransferase. A Phase I trial
3-Nitrobenzanthrone (3-NBA) is an urban air pollutant and rat lung carcinogen that is among the most potent mutagens yet tested in the Salmonella reversion assay. In the present study, 1 mg 3-NBA was administered orally to female F344 rats and DNA adduct formation was examined in liver, lung, kidney
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